N-cadherin-mediated adhesion and signaling from development to disease: lessons from mice.
N-cadherin-mediated adhesion and signaling from development to disease: lessons from mice.
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DOI：
10.1016/b978-0-12-394311-8.00012-1
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发表时间：
2013
影响因子：
--
通讯作者：
Radice GL
中科院分区：
文献类型：
--
作者：
Radice GL
在哺乳动物中鉴定的20种经典钙粘蛋白亚型中，两种最初鉴定的家族成员E-（上皮）和N-（神经）钙粘蛋白的功能已被最广泛地研究。E-钙粘蛋白和N-钙粘蛋白大多具有相互排斥的表达模式，其中E-钙粘蛋白主要在上皮细胞中表达，而N-钙粘蛋白在多种细胞中发现，包括神经、肌肉和间充质细胞。N-钙粘蛋白的功能尤其表现为细胞环境依赖性，因为它可以介导心脏中强有力的细胞间粘附，但在上皮-间充质转化（EMT）的背景下诱导细胞行为的变化，有利于迁移表型。肿瘤细胞改变其钙粘蛋白表达谱的能力，例如E-至N-钙粘蛋白，对于恶性进展至关重要。小鼠分子遗传学的最新进展，特别是组织特异性敲除和敲入N-钙粘蛋白等位基因，提供了一些意想不到的结果。本章重点介绍了一些遗传学研究，探讨了N-钙粘蛋白在胚胎发育和疾病中的复杂作用。
Of the twenty classical cadherin subtypes identified in mammals, the functions of the two initially identified family members E- (epithelial) and N- (neural) cadherin have been most extensively studied. E- and N-cadherin have mostly mutually exclusive expression patterns, with E-cadherin expressed primarily in epithelial cells whereas N-cadherin is found in a variety of cells, including neural, muscle and mesenchymal cells. N-cadherin function in particular appears to be cell-context-dependent, as it can mediate strong cell–cell adhesion in the heart, but induce changes in cell behavior in favor of a migratory phenotype in the context of epithelial–mesenchymal transition (EMT). The ability of tumor cells to alter their cadherin expression profile, e.g. E- to N-cadherin, is critical for malignant progression. Recent advances in mouse molecular genetics, and specifically tissue-specific knockout and knock-in alleles of N-cadherin, have provided some unexpected results. This chapter highlights some of the genetic studies that explored the complex role of N-cadherin in embryonic development and disease.