Activity-Dependent Clustering of Functional Synaptic Inputs on Developing Hippocampal Dendrites
Activity-Dependent Clustering of Functional Synaptic Inputs on Developing Hippocampal Dendrites
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DOI：
10.1016/j.neuron.2011.10.015
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发表时间：
2011-12-22
期刊：
影响因子：
16.2
通讯作者：
Lohmann, Christian
中科院分区：
文献类型：
--
作者：
Kleindienst, Thomas;Winnubst, Johan;Lohmann, Christian
在大脑发育过程中，在感觉系统开始发挥作用之前，神经网络会自发地产生重复性的神经元活动爆发，这种活动通常在许多神经元之间是同步的。这种活动模式已经在网络和细胞层面上有所描述，但是在自发网络活动期间单个神经元所接收的输入的精细结构尚未得到研究。在此，我们利用钙成像技术同时记录海马锥体神经元的许多突触的活动，以确定整个细胞的大多数突触的活动模式。对突触活动的时空模式的分析揭示了一种精细的连接规则：相邻突触（
During brain development, before sensory systems become functional, neuronal networks spontaneously generate repetitive bursts of neuronal activity, which are typically synchronized across many neurons. Such activity patterns have been described on the level of networks and cells, but the fine-structure of inputs received by an individual neuron during spontaneous network activity has not been studied. Here, we used calcium imaging to record activity at many synapses of hippocampal pyramidal neurons simultaneously to establish the activity patterns in the majority of synapses of an entire cell. Analysis of the spatiotemporal patterns of synaptic activity revealed a fine-scale connectivity rule: neighboring synapses (