Improving norbixin dispersibility and stability by liposomal encapsulation using the pH-driven method
Improving norbixin dispersibility and stability by liposomal encapsulation using the pH-driven method
复制标题
使用 pH 驱动方法通过脂质体封装提高降红木素的分散性和稳定性
DOI：
10.1002/jsfa.11546
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发表时间：
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影响因子：
4.1
通讯作者：
Liu Wei
中科院分区：
文献类型：
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作者：
Liu Hang;Zhang Junbing;Xiong Yong;Peng Shengfeng;McClements David Julian;Zou Liqiang;Liang Ruihong;Liu Wei
BACKGROUNDNorbixin, a carotenoid extracted from annatto seeds, is widely utilized as a natural pigment in foods, cosmetics and medicines. Its water solubility is relatively high under neutral or alkaline conditions but low under acidic conditions, which limits its application in some food products.RESULTSThis problem was overcome by utilizing liposomes to encapsulate the carotenoids so that they could be easily dispersed within acidic solutions. The norbixin was loaded into the liposomes using the pH‐driven method. Liposomes were produced by passing aqueous phospholipid dispersions through a microfluidizer under high pressure. Norbixin was then added to the liposome dispersions at pH 7.0 and then driven into the hydrophobic domains of the phospholipid bilayers by acidifying the system. Measurements of the encapsulation efficiency showed that the norbixin was successfully loaded into the liposomes using the pH‐driven method. X‐ray diffraction analysis showed that the norbixin was in an amorphous state after incorporation into the liposomes. Encapsulation of norbixin within the liposomes was also shown to increase its water dispersibility and chemical stability under acidic pH conditions.CONCLUSIONThe pH‐driven method therefore provides a useful means of increasing the application of this bioactive carotenoid within functional foods and other products. © 2021 Society of Chemical Industry.
