Caveolin 1 Expression Correlates with Poor Prognosis and Focal Adhesion Kinase Expression in Gastric Cancer
Caveolin 1 Expression Correlates with Poor Prognosis and Focal Adhesion Kinase Expression in Gastric Cancer
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DOI：
10.1159/000341685
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发表时间：
2013-01-01
期刊：
影响因子：
5
通讯作者：
Kim, Woo Ho
中科院分区：
文献类型：
--
作者：
Nam, Kyung Han;Lee, Byung Lan;Kim, Woo Ho
目的：Caveolin 1基因是肿瘤的启动子或抑制子，与肿瘤的类型和/或分期有关。目的探讨小窝蛋白1（Cav 1）在胃癌组织中的表达及其临床意义。方法：对包含405份GC标本的组织阵列切片进行免疫组化。分析Cav 1表达与临床病理因素、预后、黏着斑激酶表达、粘蛋白表型及p53表达的关系。结果：在非肿瘤性胃粘膜中，Cav 1不表达于上皮区室。在GC中，Cav 1阳性染色在405例病例中的22例（5.4%）中显示，并且在晚期GC组中显著高于早期GC组（p = 0.037）。此外，它与晚期pTNM分期（p = 0.027）和淋巴结转移（p = 0.018）显著相关。此外，生存分析显示Cav 1表达是生存不良的独立预后因素（p = 0.028）。此外，Cav 1的表达与黏着斑激酶的表达呈正相关（p = 0.034）。结论：Cav 1的表达与胃癌的进展及预后密切相关。因此，Cav 1的表达可作为胃癌诊断和治疗的补充。版权所有（C）2012 S. Karger AG，巴塞尔
Objective: Caveolin 1 gene is known as a tumor promoter or suppressor, depending on the tumor type and/or tumor stage. We aimed to investigate the clinical significance of caveolin 1 protein (Cav1) expression in gastric cancer (GC). Methods: Immunohistochemistry was performed on tissue array slides containing 405 GC specimens. The relationships between Cav1 expression and clinicopathological factors, prognosis, focal adhesion kinase expression, mucin phenotypes and p53 expression were analyzed. Results: In nonneoplastic gastric mucosa, Cav1 was not expressed in the epithelial compartment. In GC, positive staining of Cav1 was shown in 22 (5.4%) of 405 cases and was significantly higher in the advanced GC group than in the early GC group (p = 0.037). Also, it was significantly associated with advanced pTNM stage (p = 0.027) and lymph node metastasis (p = 0.018). Moreover, survival analysis showed that Cav1 expression was an independent prognostic factor of poor survival (p = 0.028). In addition, the expression of Cav1 was positively correlated with that of focal adhesion kinase (p = 0.034). Conclusions: These results indicate that the expression of Cav1 is significantly correlated with cancer progression and poor prognosis in GC. Thus, Cav1 could supplement its protein expression for the diagnosis and treatment of GC. Copyright (C) 2012 S. Karger AG, Basel