The shift from a response strategy to object-in-place strategy during learning is accompanied by a matching shift in neural firing correlates in the hippocampus.
The shift from a response strategy to object-in-place strategy during learning is accompanied by a matching shift in neural firing correlates in the hippocampus.
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DOI：
10.1101/lm.1829110
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发表时间：
2010-08
影响因子：
2
通讯作者：
Inah Lee;Jangjin Kim
中科院分区：
文献类型：
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作者：
Inah Lee;Jangjin Kim
海马依赖的任务往往涉及特定的协会之间的刺激（包括自我中心的信息），这样的任务，因此很容易受到干扰，从不相关的任务策略之前，一个正确的strategy.Using一个对象的地方配对关联任务，我们调查了在海马神经放电模式的变化与学习过程中的战略转变。我们使用了一个对象的地方配对关联任务，其中一对对象是在两个不同的武器的径向迷宫。每个物体只在一个手臂中与奖励相关，因此要求大鼠考虑物体的身份及其在迷宫中的位置。在CA1中记录的海马神经元在几天的任务获取过程中显示了其放电模式的动态转变，这与行为数据中表现出的策略转变相对应。具体来说，在老鼠学习任务之前，他们选择了一个与他们的身体保持特定自我中心关系的物体（反应策略），而不管物体的身份。然而，当动物获得任务时，它会根据其身份和迷宫中的相关位置选择物体（物体到位策略）。我们报告说，海马CA1神经元根据主导策略（即，响应与对象到位策略）在给定的学习阶段采用。结果表明，海马神经放电模式的很大程度上影响的任务需求的动物假设和灵活的变化，随着知觉的任务需求的变化。
Hippocampal-dependent tasks often involve specific associations among stimuli (including egocentric information), and such tasks are therefore prone to interference from irrelevant task strategies before a correct strategy is found. Using an object-place paired-associate task, we investigated changes in neural firing patterns in the hippocampus in association with a shift in strategy during learning. We used an object-place paired-associate task in which a pair of objects was presented in two different arms of a radial maze. Each object was associated with reward only in one of the arms, thus requiring the rats to consider both object identity and its location in the maze. Hippocampal neurons recorded in CA1 displayed a dynamic transition in their firing patterns during the acquisition of the task across days, and this corresponded to a shift in strategy manifested in behavioral data. Specifically, before the rats learned the task, they chose an object that maintained a particular egocentric relationship with their body (response strategy) irrespective of the object identity. However, as the animal acquired the task, it chose an object according to both its identity and the associated location in the maze (object-in-place strategy). We report that CA1 neurons in the hippocampus changed their prospective firing correlates according to the dominant strategy (i.e., response versus object-in-place strategy) employed at a given stage of learning. The results suggest that neural firing pattern in the hippocampus is heavily influenced by the task demand hypothesized by the animal and the firing pattern changes flexibly as the perceived task demand changes.