Acute phase reactants in allergic airway disease
Acute phase reactants in allergic airway disease
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DOI：
10.1620/tjem.204.209
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发表时间：
2004-11-01
影响因子：
2.2
通讯作者：
Çolakoglu, B
中科院分区：
文献类型：
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作者：
Büyüköztürk, S;Gelincik, AA;Çolakoglu, B
急性期反应物已被认为是各种炎症性疾病中的促炎分子。然而，关于它们在过敏性气道疾病中的作用知之甚少。本研究的目的是检测三种急性时相蛋白，即C反应蛋白（CRP），血清淀粉样蛋白A（SAA）和纤维蛋白原在过敏性鼻炎和哮喘患者的血液浓度。三个研究小组包括：非吸烟者变应性鼻炎（n = 50）、非吸烟者哮喘（n = 20）和非变应性、非吸烟者健康对照受试者（n = 20）。排除近期有上呼吸道或下呼吸道感染和创伤、任何风湿性疾病、恶性肿瘤或肥胖的患者。采集所有患者和对照组的血样，分析血清CRP、SAA和血浆纤维蛋白原。与对照组相比，鼻炎组和哮喘组的平均CRP和纤维蛋白原值无显著差异。然而，发现两组的平均SAA水平均显著高于对照组（鼻炎组p = 0.002，哮喘组p = 0.02）。FEV1值与血清标志物水平无显著相关性。本研究表明，过敏性鼻炎和哮喘患者的急性期反应物SAA升高。因此，我们认为SAA可能在炎症性气道疾病中发挥作用。(C)东北大学医学出版社.
Acute phase reactants have been implicated for their involvement as proinflammatory molecules in various inflammatory diseases. However, little is known regarding their role in the allergic airway disease. The aim of the present study was to examine the blood concentrations of three acute-phase proteins, namely C-reactive protein (CRP), serum amyloid A (SAA) and fibrinogen in patients with allergic rhinitis and asthma. Three study groups include: non-smoker allergic rhinitis (n = 50), non-smoker asthma (n = 20), and non-allergic, non-smoker healthy control subjects (n = 20). Patients who have had recent upper or lower respiratory tract infection and trauma, any rheumatological illnesses, malignancy or obesity were excluded. Blood samples were obtained from all the patients and control subjects and were analyzed for serum CRP, SAA and plasma fibrinogen. The mean CRP and fibrinogen values in the rhinitis and asthma groups were not significantly different when compared to the control group. However, the mean SAA levels of both groups were found to be significantly higher than those of the control group (p = 0.002 for rhinitis, p = 0.02 for asthma). There was no significant correlation between the FEV1 values and the levels of the serum markers. This study demonstrates that acute phase reactant SAA rises in patients with allergic rhinitis and patients with asthma. We therefore suggest that SAA may have a role in the inflammatory airway disease. (C) 2004 Tohoku University Medical Press.