AGE-RELATED DIFFERENCES IN BEHAVIOR ACROSS THE LIFE-SPAN OF THE C57BL 6J MOUSE
AGE-RELATED DIFFERENCES IN BEHAVIOR ACROSS THE LIFE-SPAN OF THE C57BL 6J MOUSE
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DOI：
10.1080/03610738108259823
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发表时间：
1981-01-01
影响因子：
1.8
通讯作者：
BARTUS, RT
中科院分区：
文献类型：
--
作者：
DEAN, RL;SCOZZAFAVA, J;BARTUS, RT
C57BL/6J小鼠代表四个不同的年龄组（从3个月到31个月不等），每只小鼠都进行了一系列行为程序测试，选择样本进行广泛的行为。这项评估表明，与其他哺乳动物物种一样，并不是老鼠的所有行为都受到年龄的影响。最严重的受损是对单次被动回避任务的保留，很可能反映了记忆能力的缺陷。在运动功能测试中，最苛刻的任务显示出年龄最大的衰弱效应，与先前在许多学习研究中报道的任务难度的影响相似。最后，在t型迷宫学习情境中，观察到一种改变原有习惯的能力缺陷，证实了老年人类和非人类灵长类动物的坚持能力增强的报告。在C57小鼠的整个生命周期中，这些结果与先前报道的其他老年哺乳动物物种的结果相似，表明某些常见类型的行为似乎随着哺乳动物物种年龄的增长而选择性地受损，并提出了这些行为缺陷可能存在共同神经学病因的可能性。
C57BL/6J mice, representing four divergent age groups (ranging from 3 months to 31 months) were each tested on a number of behavioral procedures, selected to sample a wide spectrum of behaviors. This evaluation demonstrated that, as with other mammalian species, not all behaviors in the mouse are affected by old age. Most severely impaired was retention of a single-trial passive avoidance task, most probably reflecting a deficit in memory ability. On tests of motor function, the most demanding tasks revealed the greatest debilitating effects of age, paralleling the effects of task difficulty previously reported in numerous learning studies. Finally, a deficit in the ability to modify preexisting habits in a T-maze learning situation was observed, corroborating reports of increased perseveration in aged humans and nonhuman primates. The similarity of these results across the life span of the C57 mouse with those previously reported for other aged mammalian species demonstrates that certain common types of behaviors seem to be impaired selectively by increased age across mammalian species and raises the possibility that common neurological etiologies may exist for these behavioral deficits.