The higher dietary inflammation is associated with a higher burden of multimorbidity of cardio-metabolic and mental health disorders in an urbanizing community of southern India: A cross-sectional analysis for the APCAPS cohort
The higher dietary inflammation is associated with a higher burden of multimorbidity of cardio-metabolic and mental health disorders in an urbanizing community of southern India: A cross-sectional analysis for the APCAPS cohort
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印度南部城市化社区中较高的饮食炎症与较高的心脏代谢和精神健康疾病多发病负担相关：APCAPS 队列的横断面分析
DOI：
10.1016/j.hnm.2024.200254
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发表时间：
2024
影响因子：
--
通讯作者：
Mahajan H
中科院分区：
文献类型：
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作者：
Mahajan H
背景和目标习惯饮食模式已被证明是全身炎症的主要调节因素，并被认为是心脏代谢疾病（CMD）和精神健康障碍的可改变的危险因素。我们研究了饮食炎症是否与印度南部城市化村庄的 CMD 和精神健康障碍的多发病有关。我们假设饮食炎症较高的参与者会承受较高的多发病负担。材料与方法我们对参加安得拉邦儿童和家长研究的 5984 名成年人（53% 男性）进行了横断面分析。我们使用膳食炎症指数 (DII®) 评估膳食炎症，该指数基于 27 种微量和大量营养素的摄入量，并使用经过验证的食物频率问卷进行测量。使用标准化临床程序和经过验证的问卷来评估 CMD 和精神健康障碍。 “多重发病”被定义为一种或多种 CMD（高血压、糖尿病、心肌梗塞、心力衰竭、心绞痛和中风）和一种或多种精神健康障碍（抑郁和焦虑）的共存。使用稳健的泊松回归检查多发病与饮食炎症的关联。结果多发病的患病率为 3.5%，约 75% 的参与者食用促炎症饮食（DII > 0.0）。与第一个 DII 四分位数（饮食炎症最少组）相比，第二个 DII 四分位数的调整患病率（95% 置信区间）为 1.46（0.87，2.46），第三个为 1.75（1.05，2.89），第四个 DII 四分位数为 1.77（1.06，2.96） （p-趋势 = 0.021）。没有证据表明 DII 和性别对多发病有相互作用。结论饮食炎症与多发病呈正线性相关，这表明即使适度减少饮食炎症也可能减轻多发病负担。
Background & aimsHabitual dietary pattern has been shown to be a major modulator of systemic inflammation and is considered a modifiable risk factor for cardio-metabolic diseases (CMDs) and mental health disorders. We examined whether dietary-inflammation is associated with the multimorbidity of CMDs and mental health disorders in urbanizing-villages in southern India. We hypothesized that the participants with higher dietary-inflammation would have a higher burden of multimorbidity.Materials & methodsWe conducted a cross-sectional analysis of 5984 adults (53% male) participating in the Andhra Pradesh Children and Parents' Study. We assessed dietary-inflammation using dietary inflammatory index (DII®) based on intake of 27 micro- and macro-nutrients which were measured using a validated food-frequency-questionnaires. The CMDs and mental health disorders were assessed using standardized clinical procedures and validated questionnaires. ‘Multimorbidity’ was defined as a co-existence of one or more CMDs (hypertension, diabetes, myocardial infarction, heart failure, angina and stroke) and one or more mental health disorders (depression and anxiety). The association of multimorbidity with dietary-inflammation was examined using robust Poisson regression.ResultsThe prevalence of multimorbidity was 3.5% and ∼75% of participants were consuming a pro-inflammatory diet (DII >0.0). As compared to the 1st DII-quartile (least dietary-inflammatory group), the adjusted prevalence ratio (95% confidence interval) for the presence of multimorbidity was 1.46(0.87, 2.46) for 2nd, 1.75(1.05, 2.89) for 3rd, and 1.77(1.06, 2.96) for 4th DII-quartile (p-trend = 0.021). There was no evidence of an interaction between DII and sex on multimorbidity.ConclusionsDietary-inflammation had a positive linear association with the multimorbidity, which suggest that even modest reduction in dietary-inflammation may reduce the multimorbidity burden.