Coffee intake and risk of hypertension the - Johns Hopkins precursors study
Coffee intake and risk of hypertension the - Johns Hopkins precursors study
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DOI：
10.1001/archinte.162.6.657
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发表时间：
2002-03-25
影响因子：
--
通讯作者：
Ford, DE
中科院分区：
文献类型：
--
作者：
Klag, MJ;Wang, NY;Ford, DE
背景资料：是否增加血压与咖啡饮用在临床试验中看到持续随着时间的推移，转化为高血压的发病率增加是未知的。方法：我们评估了10 - 17白色男性前医学生（平均年龄，26岁）在1948年至1964年毕业班的一个队列中的咖啡摄入量高达I-I倍，平均随访33年。每年通过自我报告确定血压和高血压的发病率，证明在该队列中是准确的。每天喝一杯咖啡会使收缩压升高0.19毫米汞柱（95%置信区间，0.02-0.35）和舒张压降低0.27 mm Hg（95%可信区间，0.15-0.39）在校正父母高血压发病率和时间依赖性体重指数、吸烟、饮酒和体力活动后，使用广义估计方程进行分析。与基线时不喝咖啡的人相比，在随访期间喝咖啡的人有更高的高血压发病率（18.8%比28.3%; P = 0.03）。与每天饮用5杯或更多杯相关的高血压相对风险（95%置信区间）在基线摄入量为1.35（0.87-2.08），在随访期间为1.60（1.06-2.40）。调整后的变量，上面列出的，但是，这些协会没有统计学显着。结论：在多年的后续行动，喝咖啡与血压的小幅增加，但似乎在高血压的发展中发挥了很小的作用。
Background: Whether the increase in blood pressure with coffee drinking seen in clinical trials persists over time and translates into an increased incidence of hypertension is not known.Methods: We assessed coffee intake in a cohort of 10 17 white male former medical students (mean age, 26 years) in graduating classes from 1948 to 1964 up to I I times over a median follow-up of 33 years. Blood pressure and incidence of hypertension were determined annually by self-report, demonstrated to be accurate in this cohort.Results: Consumption of I cup of coffee a day raised systolic blood pressure by 0.19 mm Hg (95% confidence interval, 0.02-0.35) and diastolic pressure by 0.27 mm Hg (95% confidence interval, 0.15-0.39) after adjustment for parental incidence of hypertension and time-dependent body mass index, cigarette smoking, alcohol drinking, and physical activity in analyses using generalized estimating equations. Compared with nondrinkers at baseline, coffee drinkers had a greater incidence of hypertension during follow-up (18.8% vs 28.3%; P =.03). Relative risk (95% confidence interval) of hypertension associated with drinking 5 or more cups a day was 1.35 (0.87-2.08) for baseline intake and 1.60 (1.06-2.40) for intake over follow-up. After adjustment for the variables listed above, however, these associations were not statistically significant.Conclusion: Over many years of follow-up, coffee drinking is associated with small increases in blood pressure, but appears to play a small role in the development of hypertension.