‘Mediator‐ing’ messenger RNA processing
‘Mediator‐ing’ messenger RNA processing
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DOI：
10.1002/wrna.1273
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发表时间：
2015-03
期刊：
影响因子：
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通讯作者：
Y. Huang;Xiao Yao;Gang Wang
中科院分区：
文献类型：
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作者：
Y. Huang;Xiao Yao;Gang Wang
前信使RNA（mRNA）加工，通常包括加帽，mRNA剪接和切割-聚腺苷酸化，在物理和功能上与转录相关。转录和mRNA加工之间的相互耦合确保了基因的高效和调控表达和编辑。多个转录因子/辅因子和mRNA加工因子参与偶联过程。本文综述了几个经典的例子和最近的进展，扩大了我们的理解如何转录因子或辅因子，特别是调解人复合物，有助于RNA聚合酶II延长，mRNA剪接，和聚腺苷酸化。WIREs RNA 2015，6：257-269。doi：10.1002/wrna.1273
Pre‐messenger RNA (mRNA) processing, generally including capping, mRNA splicing, and cleavage‐polyadenylation, is physically and functionally associated with transcription. The reciprocal coupling between transcription and mRNA processing ensures the efficient and regulated gene expression and editing. Multiple transcription factors/cofactors and mRNA processing factors are involved in the coupling process. This review focuses on several classic examples and recent advances that enlarge our understanding of how the transcriptional factors or cofactors, especially the Mediator complex, contribute to the RNA Pol II elongation, mRNA splicing, and polyadenylation. WIREs RNA 2015, 6:257–269. doi: 10.1002/wrna.1273