Genetic polymorphisms and oral cancer.
Genetic polymorphisms and oral cancer.
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DOI：
10.7888/juoeh.32.221
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发表时间：
2010-09
期刊：
影响因子：
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通讯作者：
Yukari Taniyama;S. Takeuchi;Y. Kuroda
中科院分区：
文献类型：
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作者：
Yukari Taniyama;S. Takeuchi;Y. Kuroda
口腔癌是一种与主要发病率和死亡率相关的疾病，是一个重要的全球性健康问题。很明显，口腔癌的主要病因是烟草和酒精暴露。研究表明，代谢活化与癌症易感性有关。各种致癌物和致癌前体，如苯并芘和亚硝胺，已被确定在烟草烟雾中，这些物质被两种类型的代谢酶激活或解毒，第一阶段和第二阶段。这些酶基因存在一定的多态性，其功能受多态性类型的影响。另一方面，除了这些酶基因之外，还有一些基因与癌症易感性有关。本文就基因多态性与口腔癌的关系作一综述。虽然有许多关于多态性与口腔癌相关的报道，但这些报道的结果是有争议的。需要进一步的研究来评估致癌物和遗传多态性之间的相互作用。
Oral cancer, a disease associated with major morbidity and mortality, represents a significant worldwide health problem. It is clear that the major etiological factors for oral cancer are tobacco and alcohol exposure. It has been shown that metabolic activation is associated with cancer susceptibility. Various carcinogens and carcinogenic precursors, such as benzopyrene and nitrosamine, have been identified in tobacco smoke, and those are activated or detoxified by two types of metabolic enzymes, phase I and phase II. There are some polymorphisms for these enzyme genes, the functions of which are modified by the types of polymorphisms. On the other hand, there are some genes besides these enzyme genes related to cancer susceptibility. In this review, we discuss the relationships between polymorphisms concerned with oral cancer. Although there are many reports on the polymorphisms related to oral cancer, the results of these reports are controversial. Further studies are needed to evaluate the interactions between carcinogens and the genetic polymorphisms.