Effects of adrenalectomy and adrenal steroids on norepinephrine synthesis and monoamine oxidase activity
Effects of adrenalectomy and adrenal steroids on norepinephrine synthesis and monoamine oxidase activity
复制标题
肾上腺切除术和肾上腺类固醇对去甲肾上腺素合成和单胺氧化酶活性的影响
DOI：
10.1016/0014-2999(78)90165-6
复制
发表时间：
1978
影响因子：
5
通讯作者：
T. Westfall
中科院分区：
文献类型：
--
作者：
J. Dailey;T. Westfall
Rat heart norepinephrine (NE) turnover was increased 6–10 days after bilateral adrenalectomy.This increase was prevented by administration of deoxycorticosterone acetate (DOCA) but not either hydrocortisone or corticosterone. Blood pressure decreased following adrenalectomy. This decrease was prevented by DOCA, hydrocortisone and corticosterone. Monoamine oxidase (MAO) activity increased in the heart but not in the liver following adrenalectomy. DOCA prevented the increase in heart MAO activity hydrocortisone and corticosterone were ineffective. In intact animals, heart and liver MAO activity were not changed by 5 days of cold exposure, a procedure which increases NE turnover. It is suggested that the increase in heart NE turnover may be related to the increase in MAO activity seen after adrenalectomy.
