Randomised controlled trial of paracetamol for heel prick pain in neonates
Randomised controlled trial of paracetamol for heel prick pain in neonates
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扑热息痛治疗新生儿足跟刺痛的随机对照试验
DOI：
10.1136/fn.79.3.f209
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
A. Ohlsson
中科院分区：
文献类型：
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作者：
Vibhuti S Shah;A. Taddio;A. Ohlsson
目的评价扑热息痛减轻足跟采血疼痛的效果。方法 对 75 名接受足跟采血的足月新生儿进行了一项前瞻性随机双盲安慰剂对照试验。手术前 60 至 90 分钟，新生儿口服扑热息痛，剂量为 20 mg/kg（第 1 组）或等体积的安慰剂（第 2 组）。足跟采血以标准化方式进行。使用面部动作百分比（眉头凸出、挤眼和鼻唇沟（范围 0-300%）和哭泣时间百分比（范围 0-100%）进行疼痛评估。结果 第 1 组有 38 名新生儿，第 2 组有 37 名新生儿。各组之间的人口统计学特征没有显着差异。平均胎龄为 39 岁（SD 1.4） 39.4 (SD 1.2) 周，p=0.86，平均出生体重 3.45 (SD 0.45) 与 3.44 (SD 0.42) kg；组 1 和 2 的面部动作疼痛评分分别没有差异 (143.5 (SD 54.2)% 与 131.1 (SD 59.6)%； p=0.38）。哭声评分也没有差异（29.4 (SD 19.9)% vs 26.8 (SD 20.2)%；p=0.60）。 结论 扑热息痛对于减轻足月新生儿足跟刺痛无效。
AIM To evaluate the effectiveness of paracetamol in decreasing the pain from heel prick. METHODS A prospective randomised double blind placebo controlled trial was conducted of 75 term neonates undergoing heel prick. Sixty to 90 minutes before the procedure neonates received paracetamol orally in a dose of 20 mg/kg (group 1) or an equal volume of placebo (group 2). Heel prick was performed in a standardised manner. Pain assessments were made using per cent facial action (brow bulge, eye squeeze, and nasolabial fold (range 0–300%) and per cent of time spent crying (range 0–100%). RESULTS Thirty eight neonates were enrolled in group 1 and 37 neonates in group 2. There were no significant differences in the demographic characteristics between groups. Mean gestational age was 39 (SD 1.4) vs 39.4 (SD 1.2) weeks, p=0.86, mean birthweight 3.45 (SD 0.45) vs 3.44 (SD 0.42) kg; p=0.31 for groups 1 and 2, respectively. Facial action pain scores did not differ between groups (143.5 (SD 54.2)% vs 131.1 (SD 59.6)%; p=0.38). Cry scores also did not differ (29.4 (SD 19.9)%vs 26.8 (SD 20.2)%; p=0.60). No adverse effects were observed. CONCLUSION Paracetamol is ineffective for decreasing the pain from heel prick in term neonates.