Estrogen-Related Receptor α: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis.
Estrogen-Related Receptor α: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis.
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雌激素相关受体α：骨稳态和骨转移的重要调节剂和有希望的目标
DOI：
10.3390/molecules27133976
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发表时间：
2022-06-21
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影响因子：
--
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骨形成和骨吸收的平衡是维持骨稳态的关键，而骨形成和骨吸收的平衡又与成骨细胞和破骨细胞的功能有关。这种平衡的破坏通常会导致骨骼疾病，包括骨质疏松症，骨关节炎和骨质疏松症。此外，骨的异常活动也有助于骨转移，骨转移经常发生在侵袭性癌症的晚期。孤儿核受体雌激素相关受体（ERRα）通过与多种分子和信号通路相互作用，调控骨细胞的命运和骨肿瘤细胞的生长。然而，这种受体在骨骼中的定义功能不一致且有争议。本文就ERRα对骨稳态和骨转移的调控作用进行综述，以期拓宽对ERRα的细胞和分子模型的认识，并进一步阐明其在临床治疗中的潜在意义。
Bone homeostasis is maintained with the balance between bone formation and bone resorption, which is involved in the functional performance of osteoblast and osteoclast. Disruption of this equilibrium usually causes bone disorders including osteoporosis, osteoarthritis, and osteosclerosis. In addition, aberrant activity of bone also contributes to the bone metastasis that frequently occurs in the late stage of aggressive cancers. Orphan nuclear receptor estrogen-related receptor (ERRα) has been demonstrated to control the bone cell fate and the progression of tumor cells in bone through crosstalk with various molecules and signaling pathways. However, the defined function of this receptor in bone is inconsistent and controversial. Therefore, we summarized the latest research and conducted an overview to reveal the regulatory effect of ERRα on bone homeostasis and bone metastasis, this review may broaden the present understanding of the cellular and molecular model of ERRα and highlight its potential implication in clinical therapy.
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