Soy isoflavones: No effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year
Soy isoflavones: No effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year
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DOI：
10.1080/07315724.2002.10719240
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发表时间：
2002-10-01
影响因子：
3.5
通讯作者：
Garner, SC
中科院分区：
文献类型：
--
作者：
Anderson, JJB;Chen, XW;Garner, SC
工作背景：在一项比较性前瞻性研究中，尚未检查富含维生素B1的大豆蛋白对健康年轻成年女性的人体骨矿物质含量（质量）和密度的影响。据报道，围绝经期和绝经后妇女显示出对骨测量的有益影响。因此，年轻女性也可以通过富含维生素B6的饮食改善其在骨巩固的早期成年期间峰值骨矿物质含量（BMC）和骨矿物质密度（BMD）的增加。目的：在这个受控的双盲干预中，我们测试了一个假设，在一年的时间里，与接受去除了大豆酮的大豆蛋白的对照组相比，富含大豆蛋白的饮食增加了年轻成年女性的BMC和BMD。任何种族背景的年轻健康女性，21至25岁，分为两组，安慰剂（n = 13）和补充剂（n = 15）。大豆蛋白补充剂富含胆甾酮（相当于每天90毫克总胆甾酮），而对照蛋白饮食缺乏胆甾酮，尽管它含有与富含胆甾酮饮食相同量的大豆蛋白和其他成分。在基线、6个月和12个月时进行BMC和BMD的双能X线吸收测量（DXA）。DXA对身体成分的估计，包括脂肪量和瘦体重，是从全身BMC测量中产生的。BMI计算为体重（kg）除以身高（m）的平方。体力活动进行了评估，并采取了三天的饮食记录在进入（基线），并在6和12 months.Results：没有变化，在BMD 12个月后，发现无论是在泼尼松治疗（治疗）组或泼尼松缺乏（对照）组。其他变量也基本上保持不变，在12个月的时间内，包括正常的月经模式在治疗和对照groups.Conclusions：富含芦荟酮的大豆制剂没有影响BMC和BMD超过12个月的时间在年轻健康的成年女性月经正常。至少在这12个月的研究期间，富含孕酮的补充剂似乎对卵巢功能正常的年轻成年女性的骨骼几乎没有影响。
Background: The effects of isoflavone-enriched soy protein on human bone mineral content (mass) and density in healthy, menstruating young adult females have not been examined in a comparative prospective investigation. Peri- and post-menopausal women have been reported to show beneficial effects of isoflavones on bone measurements. Therefore, young women may also be able to improve their accrual of peak bone mineral content (BMC) and bone mineral density (BMD) during the early adult years of bone consolidation with an isoflavone-enriched diet.Objectives: In this controlled, double-blind intervention, we tested the hypothesis that an isoflavone-rich soy protein diet increases BMC and BMD in young adult females over a period of one year in comparison to a control group receiving soy protein that has isoflavones removed.Design: Young healthy women of any ethnic background, 21 to 25 years of age, were divided into two groups, placebo (n = 13) and supplement (n = 15). The soy protein supplement was enriched with isoflavones (similar to90 mg of total isoflavones/day), whereas the control protein diet was isoflavone-deficient, even though it contained the same amount of soy protein and other ingredients as the isoflavone-rich diet. Dual-energy x-ray absorptiometric (DXA) measurements of BMC and BMD were made at baseline and at 6 and 12 months. DXA estimates of body composition, including fat mass and lean body mass, were generated from whole-body BMC measurements. BMI was calculated as weight (kg) over height (m) squared. Physical activity was assessed, and three-day dietary records were taken at entry (baseline) and at 6 and 12 months.Results: No changes in BMD after 12 months were found in either the isoflavone-treated (treatment) group or the isoflavone-deficient (control) group. Other variables also remained essentially constant over the 12-month period, including normal menstrual patterns in both the treatment and control groups.Conclusions: The isoflavone-rich soy preparation had no effects on BMC and BMD over a 12-month period in young healthy adult females with normal menses. An isoflavone-rich supplement appears to have little or no effect on bone in young adult women with normal ovarian function, at least over this 12-month study period.