ABNORMAL MATURATION PATHWAY OF KERATINOCYTES IN PSORIATIC SKIN
ABNORMAL MATURATION PATHWAY OF KERATINOCYTES IN PSORIATIC SKIN
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DOI：
10.1111/j.1365-2133.1985.tb02332.x
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发表时间：
1985-01-01
影响因子：
10.3
通讯作者：
DARMON, M
中科院分区：
文献类型：
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作者：
BERNARD, BA;ROBINSON, SM;DARMON, M
使用3种不同的标记物比较正常和银屑病表皮的成熟途径：通常在正常皮肤的颗粒层中检测到的内包蛋白，在除了基底层之外的所有受累银屑病皮肤中检测到;由鼠单克隆抗体ψ 3识别的抗原，存在于除了基底层之外的所有受累银屑病皮肤中，但在未受累和正常皮肤中不存在;而通常定位于真皮和表皮-真皮交界处的纤连蛋白也在银屑病表皮中的细胞内和细胞外被检测到。在银屑病中发现的角质形成细胞成熟的改变显然不是由正常成熟途径的截短引起的，而是反映了异常分化途径的开始，该异常分化途径的特征在于ψ 3抗原和纤连蛋白的表达以及外皮蛋白的过早出现。
The maturation pathway of normal and psoriatic epidermis were compared using 3 different markers: Involucrin, which is normally detected in the stratum granulosum in normal skin, was detected in all but the basal layer of involved psoriatic skin; an antigen, recognized by the murine monoclonal antibody .psi.3, was present in all but the basal layer of involved psoriatic skin but was absent from uninvolved and normal skin; and fibronectin, which normally localizes in the dermis and the epidermal-dermal junction, was also detected intracellularly and extracellularly in the psoriatic epidermis. The alterations in keratinocyte maturation found in psoriasis apparently do not arise from a truncation of the normal maturation pathway but rather reflect the onset of an abnormal pathway of differentiation characterized by the expression of .psi.3 antigen and fibronectin and the premature appearance of involucrin.