The role of serotonin in depression and anxiety
The role of serotonin in depression and anxiety
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DOI：
10.1016/s0924-9338(98)80015-1
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发表时间：
1998-01-01
影响因子：
7.8
通讯作者：
Deakin, JFW
中科院分区：
文献类型：
--
作者：
Deakin, JFW
对三种类型的厌恶事件（未来威胁、急性事件和慢性压力）的不同应对反应可能受到5HT预测的调节。这些应对机制的功能障碍可能分别导致：广泛性焦虑症、恐慌症和抑郁症。这一理论提出，中隔背核向5HT(2)和5HT（1D）受体的投射介导了预期性焦虑，通常激发了对威胁的回避。脑厌恶系统可能通过中缝背核5HT投射来调节预期焦虑期间的行为抑制。近端厌恶刺激如疼痛和窒息引起由杏仁核-下丘脑-导水管周围灰脑厌恶系统介导的战斗-逃跑反射。因此，惊恐发作可能是由于该系统的自发激活。中缝向5HT（1A）受体的中位突起与慢性应激抗性的适应有关。有充分的证据表明，5HT（1A）功能在抑郁症中发生破坏，导致抑郁状态。这一理论的实验测试表明，将焦虑、恐慌和抑郁视为神经化学和解剖学上特定的应对系统的功能障碍，具有启发式的作用。(C) 1998，爱思唯尔，巴黎。
The different coping responses to three types of aversive events - future threats, acute events and chronic stress - may be modulated by 5HT projections. Dysfunction in these coping mechanisms could cause, respectively: generalised anxiety disorder, panic, and depression. This theory proposes that dorsal raphe nucleus projections to 5HT(2) and 5HT(1D) receptors mediate anticipatory anxiety and normally motivate avoidance of threats. The brain aversion system may be held in check by dorsal raphe nucleus 5HT projections to mediate behavioural inhibition during anticipatory anxiety. Proximal aversive stimuli such as pain and asphyxia elicit the fight-flight reflex mediated by the amygdala-hypothalamic-periaqueductal grey brain aversion system. Panic attacks may thus be due to spontaneous activation of this system. Median raphe projections to 5HT(1A) receptors have been implicated in adaptation to chronic stress-resilence. There is good evidence that 5HT(1A) function breaks down in depression and causes the depressed state. Experimental tests of this theory suggest that viewing anxiety, panic, and depression as dysfunctions in neurochemically and anatomically specific coping systems is heuristically useful. (C) 1998, Elsevier, Paris.