Glycocalyx Remodeling with Glycopolymer-Based Proteoglycan Mimetics.
Glycocalyx Remodeling with Glycopolymer-Based Proteoglycan Mimetics.
复制标题
使用基于糖聚合物的蛋白聚糖模拟物进行糖萼重塑。
DOI：
10.1007/978-1-4939-3130-9_17
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Godula,Kamil
中科院分区：
文献类型：
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作者：
Huang,MiaL;Smith,RaymondAA;Trieger,GregW;Godula,Kamil
细胞糖萼控制着许多参与细胞发育的关键信号通路。合成材料可以模仿天然聚糖的多价和三维结构，作为破译和利用这些聚糖的作用的重要工具。在这里，我们描述了一种化学方法，用于使用合成糖模拟材料在干细胞表面进行生长因子相互作用的工程，着眼于促进它们对具有治疗潜力的特定细胞系的承诺。
The cellular glycocalyx controls many of the crucial signaling pathways involved in cellular development. Synthetic materials that can mimic the multivalency and three-dimensional architecture of native glycans serve as important tools for deciphering and exploiting the roles of these glycans. Here we describe a chemical approach for the engineering of growth-factor interactions at the surfaces of stem cells using synthetic glycomimetic materials, with an eye towards promoting their commitment towards specific cell lineages with therapeutic potential.