Chemistry of indole alkaloids related to the Corynanthe-type from Uncaria, Nauclea and Mitragyna plants
Chemistry of indole alkaloids related to the Corynanthe-type from Uncaria, Nauclea and Mitragyna plants
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DOI：
10.2174/138527205774370559
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发表时间：
2005-10-01
影响因子：
2.6
通讯作者：
Kogure, N
中科院分区：
文献类型：
--
作者：
Takayama, H;Kitajima, M;Kogure, N
许多单萜吲哚和氧化吲哚生物碱已从植物中分离得到，其中许多已被发现具有重要的药理活性，并被用作新药开发的关键先导化合物。本文综述了我们近年来对茜草科金鸡纳族（Cinchoneae）钩藤属（Uncaria）、乌核属（Nauclea）和Mitragyna属（Mitragyna）中具有Corynanthe-type骨架结构的吲哚生物碱的植物化学和合成研究结果。
A number of monoterpenoid indole and oxindole alkaloids have been isolated from botanical sources, and many of them have been found to possess significant pharmacological activities and are utilized as key lead compounds in new drug development. In this review, the recent results of our phytochemical and synthetic studies of indole alkaloids having the Corynanthe-type related skeleton from genera Uncaria, Nauclea, and Mitragyna, which are classified under tribe Cinchoneae, family Rubiaceae, are described.