3D Turbo Spin-Echo Sequence with Motion-Sensitized Driven-Equilibrium Preparation for Detection of Brain Metastases on 3T MR Imaging
3D Turbo Spin-Echo Sequence with Motion-Sensitized Driven-Equilibrium Preparation for Detection of Brain Metastases on 3T MR Imaging
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DOI：
10.3174/ajnr.a2343
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发表时间：
2011-04-01
影响因子：
3.5
通讯作者：
Honda, H.
中科院分区：
文献类型：
--
作者：
Nagao, E.;Yoshiura, T.;Honda, H.
背景和目的：MSDE制备是一种用于黑血成像的技术。我们的目的是评估的3D TSE序列与MSDE准备在检测脑转移瘤的有用性，通过比较它与传统sequences.MATERIALS和METHODS：227例患者谁被怀疑有脑转移瘤的对比后图像前瞻性地获得通过使用3 T1加权3D序列：梯度回波序列（MPDES），TSE-noMSDE，和TSE-MSDE。比较3种序列显示的血管数目和病变与正常CNR的关系。一个观察者测试涉及9名放射科医生进行了比较，他们的诊断性能使用TSE-UDE，MPRENT，并结合TSE-UDE和MPRENT通过一个FOM作为一个指数的诊断性能来自JAFROC分析，灵敏度，FP/例，和阅读time.RESULTS：TSE-UDE导致显着更好的血管抑制比其他2种方法。具有和不具有MSDE的TSE导致的CNR显着高于MPRAGE。在观察者测试中，与MPTEE相比，TSE-UDE实现了显著更高的灵敏度和FOM以及显著更短的阅读时间，但TSE-UDE的FP/例显著更高。TSE-MSDE/MPFDE的联合检测与MPFDE相比，敏感性和FOM显著提高，FP/例和阅读时间也相似。结论：与MPFDE相比，TSE-MSDE通过抑制血管和增加CNR，提高了放射科医师检测脑转移瘤的能力，但可能增加FP结果。结合MPTEST，TSE-MSDE实现了高诊断性能，同时保持低FP率。
BACKGROUND AND PURPOSE: MSDE preparation is a technique for black-blood imaging. Our purpose was to evaluate the usefulness of a 3D TSE sequence with MSDE preparation in detecting brain metastases by comparing it with conventional sequences.MATERIALS AND METHODS: Postcontrast images of 227 patients who were suspected of having brain metastasis were prospectively obtained by using 3 T1-weighted 3D sequences: a gradient-echo sequence (MPRAGE), TSE-noMSDE, and TSE-MSDE. The number of visualized blood vessels and the lesion-to-normal CNR were compared among the 3 sequences. An observer test involving 9 radiologists was performed, and their diagnostic performance by using TSE-MSDE, MPRAGE, and combined TSE-MSDE and MPRAGE was compared by means of an FOM as an index of diagnostic performance derived by the JAFROC analysis, sensitivity, FP/case, and reading time.RESULTS: TSE-MSDE resulted in significantly better vessel suppression than the other 2 methods. TSE with and without MSDE resulted in significantly higher CNRs than MPRAGE. In the observer test, significantly higher sensitivity and FOM as well as significantly shorter reading time were achieved by TSE-MSDE compared with MPRAGE, but FP/case was significantly higher with TSE-MSDE. Combined TSE-MSDE/MPRAGE resulted in significantly higher sensitivity and FOM and similar FP/case and reading time compared with MPRAGE alone.CONCLUSIONS: With blood vessel suppression and increased CNR, TSE-MSDE improves radiologists' performances in detecting brain metastases compared with MPRAGE, but it may increase FP results. Combined with MPRAGE, TSE-MSDE achieves high diagnostic performance while maintaining a low FP rate.