Interaction between circadian rhythms and stress.
Interaction between circadian rhythms and stress.
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DOI：
10.1016/j.ynstr.2016.09.001
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发表时间：
2017-02
影响因子：
5
通讯作者：
Oster H
中科院分区：
文献类型：
--
作者：
Koch CE;Leinweber B;Drengberg BC;Blaum C;Oster H
地球上的生命已经通过内部的进化适应了昼夜循环，所谓的生物钟可以调整行为和生理以适应环境条件的反复变化。在哺乳动物中，位于下丘脑视交叉上核（SCN）的主起搏器接收环境光信息，并将外周组织和中枢非SCN时钟与地球物理时间同步。调节系统，如下丘脑-垂体-肾上腺（HPA）轴和自主神经系统（ANS），都是重要的压力反应的调节，接收强昼夜输入。在这篇综述中，我们总结了昼夜节律和应激系统的相互作用以及由此产生的生理和病理生理后果。最后，我们批判性地讨论了人类啮齿动物应激研究的相关性，解决翻译方法的并发症，并从时间生物学的角度提供优化动物研究的策略。
Life on earth has adapted to the day-night cycle by evolution of internal, so-called circadian clocks that adjust behavior and physiology to the recurring changes in environmental conditions. In mammals, a master pacemaker located in the suprachiasmatic nucleus (SCN) of the hypothalamus receives environmental light information and synchronizes peripheral tissues and central non-SCN clocks to geophysical time. Regulatory systems such as the hypothalamus-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS), both being important for the regulation of stress responses, receive strong circadian input. In this review, we summarize the interaction of circadian and stress systems and the resulting physiological and pathophysiological consequences. Finally, we critically discuss the relevance of rodent stress studies for humans, addressing complications of translational approaches and offering strategies to optimize animal studies from a chronobiological perspective.