Increased coated-platelet levels in chronic haemodialysis patients.
Increased coated-platelet levels in chronic haemodialysis patients.
复制标题
慢性血液透析患者的涂层血小板水平增加。
DOI：
10.1111/j.1440-1797.2008.01026.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Jenkins,AliciaJ
中科院分区：
文献类型：
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作者：
Valaydon,ZinaS;Lee,Petrova;Dale,GeorgeL;Januszewski,AndrzejS;Rowley,KevinG;Nandurkar,Harshal;Karschimkus,Connie;Best,JamesD;Lyons,TimothyJ;Jenkins,AliciaJ
目的：确定终末期肾病血液透析患者的血小板膜水平是否升高，这种潜在的血栓前状态与心血管疾病的高风险相关。结果：透析组 ± SD包被血小板水平显著高于对照组(39.3 ± 14.3%vs 30.9 ± 10.3%，P= 0.02)。透析组高包被血小板数(40%)多于对照组(13/25 vs4/25，χ2检验，P= 0.007)。单因素相关分析显示，肾功能衰竭组包被血小板水平与血清C-反应蛋白水平呈正相关(r= 0.47，P= 0.001)，与白细胞计数呈负相关(r= −0.60，P= 0.001)。报告戒酒的透析患者的包被血小板水平高于社交饮酒者(44.3vs28.8 ± 13.5%，P= 0.01)。年龄、性别、体重、吸烟、糖尿病、血脂水平和降脂药物与包被血小板水平无相关性(P&> 0.0 5)。结论：血液透析患者包被血小板水平高于肾功能正常者，且与炎症和戒酒有关。其他血管危险因素，如吸烟、血脂和糖尿病，与包被血小板水平无关。包被的血小板可能与终末期肾病的血栓形成和血管风险增加有关。
Aim:To determine if levels of coated‐platelets, which are potentially pro‐thrombotic, are increased in end‐stage renal disease patients on haemodialysis, a condition associated with high cardiovascular disease risk.Methods:In a cross‐sectional observational study, coated‐platelet levels were measured by flow cytometry in 25 end‐stage renal failure haemodialysis patients and 25 controls without renal disease. Associations between coated‐platelet levels and clinical and biochemical factors relevant to renal and cardiovascular disease were evaluated.Results:Mean ± SD coated‐platelet levels were higher in the dialysis group than in the control group (39.3 ± 14.3%vs30.9 ± 10.3%,P= 0.02). The number of subjects with high coated‐platelet levels (>40%) was larger in the dialysis than in the control group (13/25vs4/25, χ2test,P= 0.007). On univariate analysis, coated‐platelet levels correlated with serum C‐reactive protein levels in renal failure (r= 0.47,P= 0.02) and inversely with white cell count in the control group (r= −0.60,P= 0.001). Coated‐platelet levels were higher in dialysis patients reporting alcohol abstinence than among those reporting ‘social’ drinking (44.3 ± 12.6vs28.8 ± 13.5%,P= 0.01). Age, gender, body weight, smoking, diabetes, lipid levels and lipid‐lowering drugs were not associated with coated‐platelet levels (allP> 0.05).Conclusion:Coated‐platelet levels are increased in haemodialysis patients relative to subjects with normal renal function, and are related to inflammation and alcohol abstinence. Other vascular risk factors, such as smoking, lipids and diabetes, were not related to coated‐platelet levels. Coated‐platelets may be implicated in the increased thrombosis and vascular risk in end‐stage renal disease.