Association between genetic polymorphisms of adrenergic receptor and diurnal intraocular pressure in Japanese normal-tension glaucoma.
Association between genetic polymorphisms of adrenergic receptor and diurnal intraocular pressure in Japanese normal-tension glaucoma.
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DOI：
10.1016/j.ophtha.2010.04.005
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发表时间：
2010-12
期刊：
影响因子：
13.7
通讯作者：
Yanlin Gao;M. Sakurai;H. Takeda;T. Higashide;K. Kawase;K. Sugiyama
中科院分区：
文献类型：
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作者：
Yanlin Gao;M. Sakurai;H. Takeda;T. Higashide;K. Kawase;K. Sugiyama
目的探讨日本正常眼压型青光眼（NTG）患者肾上腺素能受体（ADR）基因多态性与眼内压（IOP）的关系。前瞻性，比较案例系列。参与者：92例未经治疗的NTG患者。方法连续2天，于0600 ~ 2400 h每隔3 h测量双眼IOP。我们使用视野缺损较大的眼的IOP数据进行统计分析。每个时间点使用2天内的平均眼压。adr中α1A-、α2A-、α2B-、α2C-、β1-、β2-、β3-的遗传多态性主要通过直接DNA测序测定。分析了IOP与遗传多态性的关系。主要观察指标：遗传多态性的IOP和基因型。结果受试者每日平均眼压为14.8±2.1 mmHg（平均值±标准差）。α - 1b - adr中Del 301-303的日平均IOP （P = 0.017）、峰值IOP （P = 0.038）和低谷IOP （P = 0.046）均高于缺失(D)携带者。α2C-ADR的Del 322 ~ 325组，I/I组的日平均IOP （P = 0.037）和峰值IOP （P = 0.029）均显著低于D组。β1-ADR中S49G （A/G）的日平均眼压（P = 0.023）、峰值眼压（P = 0.019）和谷眼压（P = 0.014）均高于G携带者。对于这3个多态性，重复测量方差分析表明，主要纯合子和次要携带者的日IOP曲线平行，但日IOP水平有显著差异。结论ADR基因多态性可能改变NTG患者未经治疗的IOP水平。财务披露(S)：作者在本文中讨论的任何材料中没有专有或商业利益。
PURPOSETo evaluate the relationship between genetic polymorphisms of the adrenergic receptor (ADR) and diurnal intraocular pressure (IOP) in Japanese normal-tension glaucoma (NTG) patients.DESIGNProspective, comparative case series.PARTICIPANTSNinety-two untreated NTG patients.METHODSThe IOP of both eyes was measured at 3-hour intervals from 0600 to 2400 hours over 2 consecutive days. We used IOP data from the eye with the greater visual field defect for statistical analysis. The mean IOP over 2 days was used for each time point. Genetic polymorphisms in α1A-, α2A-, α2B-, α2C-, β1-, β2-, and β3-ADR were determined mainly by direct DNA sequencing. The relationship between IOP and genetic polymorphisms was analyzed.MAIN OUTCOME MEASUREMENTSThe IOP and genotypes of genetic polymorphisms.RESULTSDiurnal mean IOP of the subjects was 14.8±2.1 mmHg (mean value ± standard deviation). For Del 301-303 in α2B-ADR, insertion/insertion (I/I) had a significantly higher diurnal mean IOP (P = 0.017), peak IOP (P = 0.038), and trough IOP (P = 0.046) than deletion (D) carriers. For Del 322-325 in α2C-ADR, I/I had a significantly lower diurnal mean IOP (P = 0.037) and peak IOP (P = 0.029) than D carriers. For S49G (A/G) in β1-ADR, A/A had a significantly higher diurnal mean IOP (P = 0.023), peak IOP (P = 0.019), and trough IOP (P = 0.014) than G carriers. For these 3 polymorphisms, repeated measures analysis of variance showed that the major homozygotes and minor carriers had parallel diurnal IOP curves, but significantly different diurnal IOP levels.CONCLUSIONSPolymorphisms of the ADR gene may alter the untreated IOP level of patients with NTG. FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any of the materials discussed in this article.