Predicting tumor volume in radical prostatectomy specimens from patients with prostate cancer
Predicting tumor volume in radical prostatectomy specimens from patients with prostate cancer
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DOI：
10.1309/82u1089xlqgkmmn1
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发表时间：
2003-09-01
影响因子：
3.5
通讯作者：
Cheng, L
中科院分区：
文献类型：
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作者：
Eichelberger, LE;Koch, MO;Cheng, L
肿瘤体积在许多恶性肿瘤中具有预后价值;然而，前列腺腺癌肿瘤体积的确定仍然存在问题。我们检验了这样一个假设，即前列腺全切片中最大癌灶的直径可以预测整个前列腺中腺癌的体积。我们评估了184个根治性前列腺切除术标本的整个安装处理的整个前列腺。直接在载玻片上测量最大癌灶的最大直径。通过网格法计算整个前列腺中的肿瘤体积。肿瘤最大直径范围为0.1 - 4.1 cm（中位数，1.6 cm）。总肿瘤体积范围为0.1至12.5 cm（3）（中位数，1.6 cm（3））。肿瘤最大直径与肿瘤体积（斯皮尔曼相关系数= 0.84; P <0.0001）、手术切缘状态（P <0.001）、神经浸润（P <0.001）、诊断时血清前列腺特异性抗原水平（P = 0.004）、Gleason评分（P = 0.004）和病理分期（P <0.0001）之间存在显著相关性。肿瘤最大直径是肿瘤体积的预测因子，可能有助于常规处理的乳腺癌切除术标本中肿瘤体积的评估。
Tumor volume has prognostic value in numerous malignant neoplasms; however, the determination of tumor volume in prostatic adenocarcinoma remains problematic. We tested the hypothesis that the diameter of the largest focus of carcinoma in whole-mount prostate sections predicts the volume of adenocarcinoma in the entire prostate. We evaluated 184 radical prostatectomy specimens by whole-mount processing of the entire prostate. The maximum diameter of the largest focus of carcinoma was measured directly on glass slides. Tumor volume in the entire prostate was calculated by the grid method. The maximum tumor diameter ranged from 0.1 to 4.1 cm (median, 1.6 cm). The total tumor volume ranged from 0.1 to 12.5 cm(3) (median, 1.6 cm(3)). There were significant correlations between maximum tumor diameter and tumor volume (Spearman correlation coefficient = 0.84; P < .0001), surgical margin status (P < .001), perineural invasion (P < .001), serum prostate-specific antigen level at diagnosis (P = .004), Gleason score (P = .004), and pathologic stage (P < .0001). Maximum tumor diameter is a predictor of tumor volume and might be useful for the assessment of tumor volume in routinely processed prostatectomy specimens.