DISAPPEARANCE OF THYMINE DIMERS FROM DNA - ERROR-CORRECTING MECHANISM
DISAPPEARANCE OF THYMINE DIMERS FROM DNA - ERROR-CORRECTING MECHANISM
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DOI：
10.1073/pnas.51.2.226
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发表时间：
1964-01-01
影响因子：
11.1
通讯作者：
CARRIER, WL
中科院分区：
文献类型：
--
作者：
SETLOW, RB;CARRIER, WL
结果。-在大多数这项工作中使用的辐射剂量，在265 μ g/mM 2下200尔格/mM 2，停止菌株B.-，和B，，，，，15，19，并且几乎完全灭活集落形成能力。它抑制菌株15 T-，B，和B/r，“19，21中的DNA合成约60分钟，并且产生0。1%，0. 1%和10%的集落形成。两种类型的实验，间接和直接，表明细胞恢复DNA合成的能力，紫外线照射后与二聚体的状态的变化。间接实验利用了一个事实，
Results.-The radiation dose used in most of this work, 200 ergs/mM2 at 265 mu, stops DNA synthesis in strains B.-, and B,,,, 15'19 and inactivates colony-forming ability almost completely-20 It inhibits DNA synthesis for approximately 60 min in strains 15 T-, B, and B/r,''19" 21 and yields 0. 1%, 0. 1%, and 10% colony forma-tion, respectively, when cells are plated on M9 agar containing casamino acids. Two types of experiments, indirect and direct, indicate that the ability of cells to resume DNA synthesis following UV irradiation is associated with a change in the state of the dimers. The indirect experiment makes use of the fact that a