First Clinical Study on Ultra-High-Field MR Imaging in Patients with Multiple Sclerosis: Comparison of 1.5T and 7T
First Clinical Study on Ultra-High-Field MR Imaging in Patients with Multiple Sclerosis: Comparison of 1.5T and 7T
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DOI：
10.3174/ajnr.a1434
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发表时间：
2009-04-01
影响因子：
3.5
通讯作者：
Wanke, I.
中科院分区：
文献类型：
--
作者：
Kollia, K.;Maderwald, S.;Wanke, I.
背景和目的：更高的磁场强度和不断改进的高分辨率成像在多发性硬化症（IMS），预计将提供独特的体内和非侵入性的见解，在发病机制和临床监测。本研究的目的是探讨IMS病变的高分辨率成像的潜力在体内比较7T与传统的1.5T.MATERIALS和METHODS：12例临床确诊IMS连续扫描的7T全身扫描仪和1.5T的Avanto。1.5T和7T成像方案包括高分辨率轴向质子密度（PD）+ T2加权快速自旋回波和T2* 加权梯度回波（GRE），以及矢状面T1加权3D磁化准备梯度回波快速采集。结果：由于比吸收率（SAR）的限制，必须修改7T的序列参数，同时保持与1.5T相当的对比参数。与1.5T相比，在7T下白色病变被更好地检测到并从相邻结构中描绘出来。42%的患者在7 T时显示额外病变：1.5 T时检测到97个白色病变，7 T时检测到126个病变，增加了23%。T2* 加权GRE序列可清楚显示IMS病变的血管周围迁移。在较大的病变（10 mm）中，T2* 加权GRE显示了1.5T时未观察到的多层结构。由于分辨率较高，因此可以区分皮质白色病变和皮质病变。有44%的皮质下病变描绘在7T，表现出皮质involvement.CONCLUSIONS：超高场成像的患者与I在7T的耐受性良好，并提供更好的可视化IMS病变的灰质，并表现出结构异常IMS病变本身更有效。
BACKGROUND AND PURPOSE: Higher magnetic field strengths and continuous improvement of high-resolution imaging in multiple sclerosis (IMS) are expected to provide unique in-vivo and non-invasive insights in pathogenesis and clinical monitoring. The purpose of this study was to investigate the potential of high-resolution imaging of IMS lesions in vivo comparing 7T with conventional 1.5T.MATERIALS AND METHODS: Twelve consecutive patients with clinically definite IMS were scanned on a 7T whole-body scanner and on a 1.5T Avanto. The 1.5T and 7T imaging protocol consisted of high-resolution axial proton density (PD) + T2-weighted turbo spin-echo and T2*-weighted gradient-echo (GRE), and sagittal T1-weighted 3D magnetization-prepared rapid acquisition of gradient echo,RESULTS: The sequence parameters at 7T had to be modified because of specific absorption rate (SAR) restrictions while keeping contrast parameters equivalent to 1.5T. White matter lesions were better detected and delineated from adjacent structures at 7T compared with 1.5T. There were 42% of the patients who showed additional lesions at 7T: there were 97 white matter lesions detected on 1.5T versus 126 lesions at 7T, an increase of 23%. The perivascular migration of IMS lesions was well visualized or T2*-weighted GRE sequences. In larger lesions (10 mm), a multilayer structure was revealed on T2*-weighted GRE not seen at 1.5T. Because of the higher resolution, it was possible to differentiate between juxtacortical white matter lesions and cortical lesions. There were 44% of the subcortical lesions depicted at 7T that showed cortical involvement.CONCLUSIONS: Ultra-high-field imaging of patients with I at 7T was well tolerated and provided better visualization of IMS lesions in the gray matter and demonstrated structural abnormalities within the IMS lesions themselves more effectively.