Motivation and its Relationship to Neurocognition, Social Cognition, and Functional Outcome in Schizophrenia
Motivation and its Relationship to Neurocognition, Social Cognition, and Functional Outcome in Schizophrenia
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DOI：
10.1016/j.schres.2009.08.015
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发表时间：
2009-11-01
影响因子：
4.5
通讯作者：
Vinogradov, Sophia
中科院分区：
文献类型：
--
作者：
Gard, David E.;Fisher, Melissa;Vinogradov, Sophia
目的：一个新兴的研究领域已经集中在精神分裂症的动机缺陷，产生的作用，动机在众所周知的神经认知和功能结果之间的关系的假设。然而，很少有研究动机的作用，在更复杂的模型的结果，包括社会认知，尽管我们越来越多地了解社会认知的关键作用，在社区功能的精神分裂症，尽管新的基础科学发现之间的关联社会认知和奖励处理在人类的神经系统。使用路径分析，我们直接，对比动机是否1）因果影响已知的社会认知缺陷的精神分裂症，导致不良的结果或2）介导社会认知缺陷和结果之间的关系在这种疾病。方法：91例精神分裂症或情感性精神障碍患者完成了访谈，基于动机和功能结果的测量以及神经认知和社会认知的标准化测量。根据最近的研究，动机似乎介导神经认知，社会认知和功能结果之间的关系。一个模型与动机作为因果因素导致在不适合表明动机并没有出现之前neurocognition.Conclusions：在本研究中的结果表明，动机起着显着的神经认知，社会认知和功能结果之间的中介作用。潜在的心理社会治疗的影响进行了讨论，特别是那些强调社会认知和动机的增强。由爱思唯尔公司出版
Objective: A burgeoning area of research has focused on motivational deficits in schizophrenia, producing hypotheses about the role that motivation plays in the well-known relationship between neurocognition and functional outcome. However, little work has examined the role of motivation in more complex models of outcome that include social cognition, despite our increased understanding of the critical role of social cognition in community functioning in schizophrenia, and despite new basic science findings on the association between social cognitive and reward processing in neural systems in humans. Using path analysis, we directly, contrasted whether motivation 1) causally influences known social cognitive deficits in schizophrenia, leading to poor outcome or 2) mediates the relationship between social cognitive deficits and outcome in this illness.Method: Ninety one patients with schizophrenia or schizoaffective disorder completed interview-based measures of motivation and functional outcome as well as standardized measures of neurocognition and social cognition in a cross-sectional design.Results: In line with recent research, motivation appears to mediate the relationship between neurocognition, social cognition and functional outcome. A model with motivation as a causal factor resulted in poor fit indicating that motivation does not appear to precede neurocognition.Conclusions: Findings in the present study indicate that motivation plays a significant and mediating role between neurocognition, social cognition, and functional outcome. Potential psychosocial treatment implications are discussed, especially those that emphasize social cognitive and motivational enhancement. Published by Elsevier B.V.