Open Microfluidic Capillary Systems
Open Microfluidic Capillary Systems
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DOI：
10.1021/acs.analchem.9b01429
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发表时间：
2019-07-16
影响因子：
7.4
通讯作者：
Theberge, Ashleigh B.
中科院分区：
文献类型：
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作者：
Berthier, Erwin;Dostie, Ashley M.;Theberge, Ashleigh B.
开放式微流体毛细管系统是微流体学中一个快速发展的分支，在该系统中，流体是通过毛细管力在四周无物理壁的通道中进行操控的。典型的通道几何形状包括凹槽、轨道或梁以及具有多个气 - 液界面的复杂系统。去除通道壁使得在通道中的任何位置都能够进行提取（流体取样）和添加（移液添加试剂或添加诸如组织支架之类的物体）；整个通道成为一个“设备 - 外界”接口，而在传统的封闭通道微流体系统中，此类接口仅限于设备的入口和出口。开放式微流体毛细管系统制造简单且运行可靠。原型制作方法（例如3D打印）和制造方法（例如注塑成型）可以无缝使用，从而加速开发。本综述重点介绍了开放式微流体毛细管系统的基本原理，包括独特优势、设计考量、制造方法以及对流动的分析考量；可组合以创建用于流体操控的“工具箱”的设备特征；以及在生物学、诊断学、化学、传感和双相应用中的应用。
Open microfluidic capillary systems are a rapidly evolving branch of microfluidics where fluids are manipulated by capillary forces in channels lacking physical walls on all sides. Typical channel geometries include grooves, rails, or beams and complex systems with multiple air-liquid interfaces. Removing channel walls allows access for retrieval (fluid sampling) and addition (pipetting reagents or adding objects like tissue scaffolds) at any point in the channel; the entire channel becomes a "device-to-world" interface, whereas such interfaces are limited to device inlets and outlets in traditional closed-channel microfluidics. Open microfluidic capillary systems are simple to fabricate and reliable to operate. Prototyping methods (e.g., 3D printing) and manufacturing methods (e.g., injection molding) can be used seamlessly, accelerating development. This Perspective highlights fundamentals of open microfluidic capillary systems including unique advantages, design considerations, fabrication methods, and analytical considerations for flow; device features that can be combined to create a "toolbox" for fluid manipulation; and applications in biology, diagnostics, chemistry, sensing, and biphasic applications.