Prescription Opioids in Adolescence and Future Opioid Misuse
Prescription Opioids in Adolescence and Future Opioid Misuse
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DOI：
10.1542/peds.2015-1364
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发表时间：
2015-11-01
期刊：
影响因子：
8
通讯作者：
Heard, Kennon
中科院分区：
文献类型：
--
作者：
Miech, Richard;Johnston, Lloyd;Heard, Kennon
背景和目的：合法使用阿片类药物与成人长期使用抽象阿片类药物和可能误用的风险增加有关。本研究的目的是估计未来阿片类药物滥用的风险青少年谁还没有从高中毕业。方法：前瞻性，面板数据来自监测未来的研究。该分析使用了一个全国代表性的样本，在12年级的学校调查了6220人，然后随访到23岁。根据已知的风险因素在12年级测量的预测未来阿片类药物滥用对分析进行分层。主要结果是19至23岁的处方阿片类药物的非医疗使用。预测因素包括使用合法处方的12年级，以及基线的药物使用史和基线的态度对非法药物use.RESULTS：合法的阿片类药物使用高中毕业前是独立的，与未来阿片类药物滥用的风险增加了33%，高中后。这种关联是集中在个人谁有很少或没有吸毒史，以及强烈反对非法药物使用在baseline.CONCLUSIONS：使用处方阿片类药物前12年级是独立相关的未来阿片类药物滥用的患者很少的药物经验，谁不赞成非法药物的使用。以诊所为基础的教育和预防工作有很大的潜力，以减少未来阿片类药物滥用的这些人，谁开始阿片类药物的使用与强烈的态度，反对非法药物的使用。
BACKGROUND AND OBJECTIVE: Legitimate opioid use is associated with an increased risk of long-term abstract opioid use and possibly misuse in adults. The objective of this study was to estimate the risk of future opioid misuse among adolescents who have not yet graduated from high school.METHODS: Prospective, panel data come from the Monitoring the Future study. The analysis uses a nationally representative sample of 6220 individuals surveyed in school in 12th grade and then followed up through age 23. Analyses are stratified by predicted future opioid misuse as measured in 12th grade on the basis of known risk factors. The main outcome is nonmedical use of a prescription opioid at ages 19 to 23. Predictors include use of a legitimate prescription by 12th grade, as well as baseline history of drug use and baseline attitudes toward illegal drug use.RESULTS: Legitimate opioid use before high school graduation is independently associated with a 33% increase in the risk of future opioid misuse after high school. This association is concentrated among individuals who have little to no history of drug use and, as well, strong disapproval of illegal drug use at baseline.CONCLUSIONS: Use of prescribed opioids before the 12th grade is independently associated with future opioid misuse among patients with little drug experience and who disapprove of illegal drug use. Clinic-based education and prevention efforts have substantial potential to reduce future opioid misuse among these individuals, who begin opioid use with strong attitudes against illegal drug use.