ICAM-1 participates in the entry of West Nile virus into the central nervous system
ICAM-1 participates in the entry of West Nile virus into the central nervous system
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DOI：
10.1128/jvi.02621-07
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发表时间：
2008-04-01
影响因子：
5.4
通讯作者：
Fikrig, Erol
中科院分区：
文献类型：
--
作者：
Dai, Jianfeng;Wang, Penghua;Fikrig, Erol
确定西尼罗河病毒如何穿过血脑屏障对于了解脑炎的发病机制至关重要。在这里，我们表明，ICAM-1（-/-）小鼠比对照动物更能抵抗致命的西尼罗河脑炎。ICAM-1（-/-）小鼠与对照组相比，病毒载量较低，白细胞浸润减少，脑神经元损伤减少。这与病毒感染后血脑屏障渗漏减少有关。这些数据表明，ICAM-1在西尼罗河病毒神经侵袭中起着重要作用，靶向ICAM-1信号传导可能有助于控制病毒性脑炎。
Determining how West Nile virus crosses the blood-brain barrier is critical to understanding the pathogenesis of encephalitis. Here, we show that ICAM-1(-/-) mice are more resistant than control animals to lethal West Nile encephalitis. ICAM-1(-/-) mice have a lower viral load, reduced leukocyte infiltration, and diminished neuronal damage in the brain compared to control animals. This is associated with decreased blood-brain barrier leakage after viral infection. These data suggest that ICAM-1 plays an important role in West Nile virus neuroinvasion and that targeting ICAM-1 signaling may help control viral encephalitis.