Distribution of Peyer's patches in the distal ileum
Distribution of Peyer's patches in the distal ileum
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DOI：
10.1097/00054725-200205000-00004
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发表时间：
2002-05-01
影响因子：
4.9
通讯作者：
Holmes, KA
中科院分区：
文献类型：
--
作者：
Van Kruiningen, HJ;West, AB;Holmes, KA
背景与目的：Peyer's补丁在肠道免疫中起重要作用，是重要病原体的入口，可能在克罗恩病中起重要作用。然而，它们的显微解剖和免疫功能被很好地描述。令人惊讶的是，人们对它们的宏观解剖结构和分布知之甚少。我们的目的是估计他们的人数。区域。分布在正常的回肠远端。特别是病人的年龄。方法：55例无肠道疾病的成人尸体解剖取远端回肠（200 cm），沿肠系膜边缘切开。固定在醋酸中。透照。Peyer的补丁被计数。长度。宽度。和回盲值的距离，记录在这里。结果：斑块在终末10 ~ 15cm处最多，形成淋巴环状。更多近端斑块呈椭圆形，反肠系膜状，间距不规则。按面积计算，46%的斑块组织出现在末端25cm处。平均斑块数从最年轻组的29.4 +/- 5.4到最年长组的19.0 +/- 3.0不等。总斑块面积以21 ~ 30岁组最大（47.4±1.0 cm(2)）。结论：Peyer补片集中于回肠远端25 cm，近端延伸200 cm。它们的大小、形状和分布在不同个体中的差异比通常认为的要大，并可能影响以这些结构为中心的疾病的表现。
Background and Aims: Peyer's patches play a major role in intestinal immunity, are portals of entry for significant pathogens, and may be important in Crohn's disease. Whereas their microscopic anatomy and immune function are well described. surprisingly little is known of their macroscopic anatomy and distribution. Our aim was to assess their number. area. and distribution in the normal distal ileum. with particular reference to patient age. Methods: Distal ilea (200 cm) obtained Lit autopsy from 55 adults without intestinal disease were opened along the mesenteric border. fixed in acetic acid. and transilluminated. Peyer's patches were counted. and the length. breadth. and distance from the ileocecal value,here recorded. Results: Patches were most numerous in the terminal 10-15 cm where they formed a lymphoid ring. More proximal patches were oval, antimesenteric, and irregularly spaced. By area, 46% of patch tissue occurred in the terminal 25 cm. The mean number of patches ranged from 29.4 +/- 5.4 in the youngest group studied, to 19.0 +/- 3.0 in the oldest. Total patch area was greatest in the group aged 21-30 (47.4 +/- 1.0 cm(2)). Conclusion: Peyer's patches are concentrated in the distal 25 cm of ileum but extend proximally for 200 cm. The variation in their size, shape, and distribution in different individuals is greater than often appreciated and may influence the presentation of diseases centered on these structures.