Nuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patients
Nuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patients
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DOI：
10.1016/j.urolonc.2010.12.016
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发表时间：
2012-07-01
影响因子：
2.7
通讯作者：
Song, Xishuang
中科院分区：
文献类型：
--
作者：
Che, Xiangyu;Yang, Deyong;Song, Xishuang
目的：目的探讨细胞凋亡抑制蛋白1（cIAP 1）和细胞凋亡抑制蛋白2（cIAP 2）在膀胱癌（BCC）中的表达及其与预后的关系。采用免疫组织化学方法检测了32例正常人和102例连续接受手术治疗的患者的膀胱标本中cIAP 1和cIAP 2的表达。从2004年1月到2005年12月，我们部门的业务。细胞质cIAP 1和cIAP 2表达评分为0（阴性）、+1（弱）、+2（中等）和+3（强）。核cIAP 1表达评分为0（0%）、+1（1%-25%）、+2（26%-50%）和+3（>50%）。结果：cIAP 1、cIAP 2在膀胱癌组织中的表达明显高于正常膀胱组织（cIAP 1-C：P < 0.01，cIAP 2-C：P = 0.017，cIAP 1-N：P < 0.01）。cIAP 1核染色（cIAP 1-N）与肿瘤分期（肌层浸润vs非肌层浸润，P = 0.03）和肿瘤分级（低vs高，P = 0.01）显著相关。与低cIAP 1-N组相比，高cIAP 1-N组的平均总生存期和平均无复发生存期均显著降低（低cIAP 1-N：平均总生存期62.7个月，高cIAP 1-N：平均总生存期45.6个月，P < 0.01;低cIAP 1-N：平均无复发生存期44.2个月，高cIAP 1-N：平均无复发生存期30.1个月（P < 0.01）。结论：cIAP 1-N表达与膀胱癌分期、分级、复发及死亡密切相关。该标志物表达似乎也是膀胱癌预后的标志物。(C)2012 Elsevier Inc. All rights reserved.
Purpose: To evaluate the tumor-related exbression profile of cellular inhibitor of apoptosis protein 1 (cIAP1) and cellular inhibitor of apoptosis protein (cIAP2) in patients with bladder cell carcinoma (BCC) and to investigate its potential prognostic value.Methods: The expression of cIAP1 and cIAP2 was examined immunohistochemically in archival bladder specimens from 32 normal controls and 102 consecutive patients who underwent surgical operations at our department from January 2004 through December 2005. Cytoplasm cIAP1 and cIAP2 expression was scored as 0 (negative), +1 (weak), +2 (medium), and +3 (strong). Nuclear cIAP1 expression was scored as 0 (0%), +1 (1%-25%), +2 (26%-50%), and +3 (>50%). Proliferation was determined by Ki67 staining as percentage of positive cells.Results: cIAP1 and cIAP2 expression were significantly increased in bladder cancer compared with normal bladder urothelium (cIAP1-C: P < 0.01, cIAP2-C: P = 0.017, cIAP1-N: P < 0.01). Nuclear staining of cIAP1 (cIAP1-N) was significantly associated with tumor stage (muscle invasive vs. non-muscle invasive, P = 0.03) and tumor grade (low vs. high, P = 0.01). Both the mean overall survival and mean recurrence-free survival were significantly decreased in the high cIAP1-N group compared to the low cIAP1-N group (low cIAP1-N: mean overall survival 62.7 months, high cIAP1-N: mean overall survival 45.6 months, P < 0.01; low cIAP1-N: mean recurrence-free survival 44.2 months, high cIAP1-N: mean recurrence-free survival 30.1 months, P < 0.01). cIAP1-N expression correlated strongly with KI67 expression (r = 0.744, P < 0.01).Conclusion: Nuclear cIAP-1 expression strongly correlated to bladder cancer stage, tumor grade, tumor recurrence and tumor related death. This marker expression was also appears to be a marker in bladder cancer prognosis. (C) 2012 Elsevier Inc. All rights reserved.