Doors P300 moderates the relationship between reward positivity and current depression status in adults.
Doors P300 moderates the relationship between reward positivity and current depression status in adults.
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Doors P300 调节成人奖励积极性与当前抑郁状态之间的关系。
DOI：
10.1016/j.jad.2021.07.091
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发表时间：
2021
影响因子：
6.6
通讯作者：
Hajcak,Greg
中科院分区：
文献类型：
--
作者：
Santopetro,NicholasJ;Brush,CJ;Burani,Kreshnik;Bruchnak,Alec;Hajcak,Greg
背景：先前的研究发现，与抑郁症相关的事件相关电位(ERP)的奖励正性(RewP)和P300成分都存在缺陷。本研究考察了赌博任务中命令性刺激诱发的P300是否与抑郁有关，并与REWP一起使用，以更好地解释抑郁的个体差异。方法：在本研究中，80名患有抑郁症的成年人(MAGE=339.65，79%女性)和43名健康对照(MAGE=937.02，81%女性)完成了临床访谈、自我报告问卷和DOORS赌博任务，同时记录了EEG。结果：结果表明，抑郁症患者对DOORS刺激(即DOORS P300)的P300降低，尤其是在报告快感缺乏的抑郁者。获得和损失反馈P300在不同组之间没有差异。此外，DOORS P300缓和了REWP和抑郁状态之间的联系：奖励处理相对完整(即REWP较大)的个体如果表现出较低的P300，则更有可能目前患有抑郁症。限制：大多数样本被确定为高加索人，这降低了当前结果的概括性。此外，目前的研究是横断面设计，这限制了对这些ERP如何与障碍的变化相吻合的洞察。结论：本研究表明，在当前抑郁的个体中，门刺激的一个新的P300成分似乎被钝化，并且将门P300与REWP结合使用可以显著解释抑郁症的差异。
Background:Previous research has found deficits in both the reward positivity (RewP) and P300 components of the event-related potential (ERP) in relation to depression. The current study examined whether the P300, elicited from imperative stimuli in a gambling task, relates to depression – and can be utilized in tandem with the RewP to better account for individual differences in depression.Methods:In the current study, 80 adults with current depression (Mage= 39.65, 79% female) and 43 healthy controls (Mage= 37.02, 81% female) completed clinical interviews, self-report questionnaires, and the doors gambling task while EEG was recorded.Results:Results indicated a reduced P300 to doors stimuli (i.e., doors P300) in depression, especially among depressed individuals reporting heightened anhedonia. Gain and loss feedback P300s did not differ between groups. Moreover, the doors P300 moderated the association between RewP and depression status: individuals with relatively intact reward processing (i.e., larger RewP) were more likely to be currently depressed if they exhibited a reduced P300.Limitations:The majority of the sample identified as Caucasian which reduces generalizability of current results. Additionally, the current study is cross sectional design which limits insight into how these ERPs coincide with changes in the disorder.Conclusions:The current study demonstrates that a novel P300 component to the doors stimulus appears to be blunted in currently depressed individuals, and that using the doors P300 in combination with the RewP accounts for significantly more variance in depression.