Treating Pemphigus Vulgaris with Prednisone and Mycophenolate Mofetil: A Multicenter, Randomized, Placebo-Controlled Trial
Treating Pemphigus Vulgaris with Prednisone and Mycophenolate Mofetil: A Multicenter, Randomized, Placebo-Controlled Trial
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DOI：
10.1038/jid.2010.91
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发表时间：
2010-08-01
影响因子：
6.5
通讯作者：
Anhalt, Grant J.
中科院分区：
文献类型：
--
作者：
Beissert, Stefan;Mimouni, Daniel;Anhalt, Grant J.
寻常天疱疮的非盲试验表明，霉酚酸酯（MMF）可能是有益的。在一项前瞻性、多中心试验中，轻度或中度寻常天疱疮门诊患者随机接受MMF（2或3 g/天（-1））+口服皮质类固醇或安慰剂+口服皮质类固醇治疗52周。主要终点是安慰剂组和联合MMF组中对治疗有反应的患者比例（无新发、持续性口腔或皮肤病变，以及泼尼松剂量
Non-blinded trials of pemphigus vulgaris suggest that mycophenolate mofetil (MMF) may be beneficial. In a prospective, multicenter trial, outpatients with mild or moderate pemphigus vulgaris were randomized to MMF (2 or 3 g day(-1)) plus oral corticosteroids or placebo plus oral corticosteroids for 52 weeks. The primary end point was the proportion of patients in the placebo and combined MMF groups responding to treatment (absence of new, persistent oral or cutaneous lesions, and prednisone dose