Effects of alendronate on metacarpal and lumbar bone mineral density, bone resorption, and chronic back pain in postmenopausal women with osteoporosis (Retracted Article)
Effects of alendronate on metacarpal and lumbar bone mineral density, bone resorption, and chronic back pain in postmenopausal women with osteoporosis (Retracted Article)
复制标题
DOI：
10.1007/s10067-004-0881-z
复制
发表时间：
2004-10-01
影响因子：
3.4
通讯作者：
Uzawa, M
中科院分区：
文献类型：
--
作者：
Iwamoto, J;Takeda, T;Uzawa, M
本研究的目的是探讨阿仑膦酸钠对绝经后骨质疏松妇女掌骨和腰椎骨密度（BMD）、骨吸收和慢性背痛的影响。选择绝经后骨质疏松妇女80例，年龄59-88岁，按骨密度测定部位分为掌骨（M）和腰椎（L）两组，每组40例。阿仑膦酸钠5 mg/d，疗程12个月。分别在基线和每6个月通过计算机X线密度测定法或双能X线吸收测定法测量M组或L组的掌骨或腰椎BMD。采用酶联免疫吸附法测定两组患者尿I型胶原N端交联肽（NTX）水平，并在基线和每6个月进行一次面部量表评分。两组患者的基线特征，包括年龄、体重指数、绝经年限、尿NTX水平、面部量表评分或每例患者的普遍椎骨骨折数量无显著差异。两组尿NTX水平降低，慢性背痛改善相似。M组掌骨BMD无显著变化（增加0.20%），L组腰椎BMD增加8.15%。这些结果表明，虽然阿仑膦酸钠增加腰椎的骨密度，这是丰富的松质骨，并改善慢性背痛，抑制骨质疏松症绝经后妇女的骨吸收，它可能无法增加掌骨，上肢远端部位的皮质骨密度。
The purpose of this study was to investigate the effect of alendronate on metacarpal and lumbar bone mineral density (BMD), bone resorption, and chronic back pain in postmenopausal women with osteoporosis. Eighty postmenopausal women with osteoporosis, 59-88 years of age, were divided into two groups of 40 each according to the site of BMD measurement: the metacarpus (M) and the lumbar spine (L). All of them were treated with alendronate (5 mg/day) for 12 months. Metacarpal or lumbar BMD was measured by computed X-ray densitometry or dual-energy X-ray absorptiometry in the M or the L group, respectively, at baseline and every 6 months. Urinary cross-linked N-terminal telopeptides of type I collagen (NTX) were measured by enzyme-linked immunosorbent assay, and chronic back pain was evaluated by face scale score at baseline and every 6 months in both groups. There were no significant differences in baseline characteristics, including age, body mass index, years since menopause, urinary NTX level, face scale score, or number of prevalent vertebral fractures per patient between the two groups. Urinary NTX level was reduced and chronic back pain was improved similarly in both groups. Whereas metacarpal BMD did not significantly change in the M group (0.20% increase), lumbar BMD increased by 8.15% in the L group. These results suggest that although alendronate increases BMD of the lumbar spine, which is rich in cancellous bone, and improves chronic back pain, with suppression of bone resorption in postmenopausal women with osteoporosis, it may fail to increase cortical BMD of the metacarpus, a distal site of the upper extremity.