Basic Science Review: The Myopathy of Peripheral Arterial Occlusive Disease: Part 2. Oxidative Stress, Neuropathy, and Shift in Muscle Fiber Type
Basic Science Review: The Myopathy of Peripheral Arterial Occlusive Disease: Part 2. Oxidative Stress, Neuropathy, and Shift in Muscle Fiber Type
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基础科学评论：外周动脉闭塞性疾病的肌病：第 2 部分：氧化应激、神经病变和肌纤维类型的转变
DOI：
--
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发表时间：
2008
影响因子：
0.9
通讯作者：
S. Dodd
中科院分区：
文献类型：
--
作者：
I. Pipinos;A. Judge;J. Selsby;Zhen Zhu;S. Swanson;A. Nella;S. Dodd
近年来，越来越多的研究表明，肌病是外周动脉闭塞性疾病的存在、贡献，并在一定程度上决定了其发病机制。这些工作提供的证据表明，运动诱导的缺血和静息再灌注的重复循环状态在周围动脉闭塞疾病患者中起作用，并介导肌肉的大量结构和代谢变化，导致力量和功能的降低。在这一过程中的关键角色似乎是有缺陷的线粒体，它通过作为能量、氧自由基物种和细胞凋亡调节器的多个层面的失效，产生并维持肌肉性能的进行性下降。在这篇由两部分组成的综述中，强调了目前可用的证据，这些证据表征了这种肌病的性质和机制。第一部分对肌病的功能和组织形态特征进行了综述，重点介绍了线粒体病的生物化学和生物能量学。第二部分综述了与缺血再灌注相关的氧化应激可能是周围动脉闭塞性疾病肌病的主要作用机制的证据。重要的新发现，一种可能的神经病变和肌肉纤维类型的转变也进行了回顾。更多地了解这些机制将加强我们对它们可预防和可治疗程度的理解。
In recent years, an increasing number of studies have demonstrated that a myopathy is present, contributes, and, to a certain extent, determines the pathogenesis of peripheral arterial occlusive disease. These works provide evidence that a state of repetitive cycles of exercise-induced ischemia followed by reperfusion at rest operates in patients with peripheral arterial occlusive disease and mediates a large number of structural and metabolic changes in the muscle, resulting in reduced strength and function. The key players in this process appear to be defective mitochondria that, through multilevel failure in their roles as energy, oxygen radical species, and apoptosis regulators, produce and sustain a progressive decline in muscle performance. In this 2-part review, the currently available evidence that characterizes the nature and mechanisms responsible for this myopathy is highlighted. In part 1, the functional and histomorphological characteristics of the myopathy were reviewed, and the main focus was on the biochemistry and bioenergetics of its mitochondriopathy. In part 2, accumulating evidence that oxidative stress related to ischemia reperfusion is probably the major operating mechanism of peripheral arterial occlusive disease myopathy is reviewed. Important new findings of a possible neuropathy and a shift in muscle fiber type are also reviewed. Learning more about these mechanisms will enhance our understanding of the degree to which they are preventable and treatable.
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影响因子：
3.9
作者：
Moghaddas, S;Hoppel, CL;Lesnefsky, EJ
通讯作者：
Lesnefsky, EJ
影响因子：
4.8
作者：
Wallace, DC
通讯作者：
Wallace, DC
影响因子：
3.2
作者：
Scott, W;Stevens, J;Binder-Macleod, SA
通讯作者：
Binder-Macleod, SA
影响因子：
3.9
作者：
Kwong, LK;Sohal, RS
通讯作者：
Sohal, RS
缺氧、缺血和炎症。
DOI：
--
发表时间：
1986
期刊：
Acta physiologica Scandinavica. Supplementum
影响因子：
--
作者：
Weiss,SJ
通讯作者：
Weiss,SJ