Conserved aging-related signatures of senescence and inflammation in different tissues and species
Conserved aging-related signatures of senescence and inflammation in different tissues and species
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DOI：
10.18632/aging.102345
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发表时间：
2019-10-15
期刊：
影响因子：
5.2
通讯作者：
Marz, Manja
中科院分区：
文献类型：
--
作者：
Barth, Emanuel;Srivastava, Akash;Marz, Manja
越来越多的证据表明，慢性炎症和衰老是许多严重的年龄相关疾病的原因，这两个生物过程在衰老过程中高度上调。然而，到目前为止，仍然不清楚是否存在特定的炎症或衰老相关基因，这些基因在不同物种或组织之间是常见的。这些潜在的衰老标志物可能有助于确定与衰老相关的疾病的治疗干预的可能目标，也可能加深我们对衰老主要机制的理解。为了识别衰老和组织特异性衰老标志物的特征，我们分析了来自四种进化上不同的物种（人类、小鼠和两种鱼）和四种不同组织（血液、大脑、肝脏）的大量横断面RNA测序数据。和皮肤）。在至少三个不同的物种和三个不同的组织中，我们发现了几个显示出相似表达模式的基因，这些基因可能作为潜在的衰老标记。此外，我们还发现，与衰老相关的基因在长寿个体中往往比在平均寿命个体中受到更严格的控制。这些观察结果暗示了影响个体寿命的一般遗传水平。总而言之，这项描述性研究有助于更好地了解常见的衰老特征以及特定组织的衰老模式，并为进一步的年龄相关调查研究提供基础。
Increasing evidence indicates that chronic inflammation and senescence are the cause of many severe age-related diseases, with both biological processes highly upregulated during aging. However, until now, it has remained unknown whether specific inflammation- or senescence-related genes exist that are common between different species or tissues. These potential markers of aging could help to identify possible targets for therapeutic interventions of aging-associated afflictions and might also deepen our understanding of the principal mechanisms of aging. With the objective of identifying such signatures of aging and tissue-specific aging markers, we analyzed a multitude of cross-sectional RNA-Seq data from four evolutionarily distinct species (human, mouse and two fish) and four different tissues (blood, brain, liver and skin). In at least three different species and three different tissues, we identified several genes that displayed similar expression patterns that might serve as potential aging markers. Additionally, we show that genes involved in aging-related processes tend to be tighter controlled in long-lived than in average-lived individuals. These observations hint at a general genetic level that affect an individual's life span. Altogether, this descriptive study contributes to a better understanding of common aging signatures as well as tissue-specific aging patterns and supplies the basis for further investigative age-related studies.