Using a 1 M Gd-chelate (gadobutrol) for total-body three-dimensional MR angiography:: preliminary experience
Using a 1 M Gd-chelate (gadobutrol) for total-body three-dimensional MR angiography:: preliminary experience
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DOI：
10.1002/jmri.10302
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发表时间：
2003-05-01
影响因子：
4.4
通讯作者：
Ruehm, SG
中科院分区：
文献类型：
--
作者：
Goyen, M;Herborn, CU;Ruehm, SG
目的：确定高浓度钆螯合物是否有利于最近引入的全身磁共振血管造影（MRA）概念，允许在仅仅72秒内覆盖全身，从颈动脉延伸到径流血管。材料与方法：对3名健康志愿者和连续10名dsa记录的外周血管疾病患者进行全身三维（3D） MRA，使用剂量为1 M的gd -螯合剂（gadobutrol, Gadovisto, Schering, Berlin, Germany），剂量为0.2 mmol/kg体重（双相注射方案：1.3 mL/秒和0.7 mL/秒）。三名健康志愿者相隔至少72小时，也接受了相同的核磁共振成像方案，使用等摩尔剂量的加多戊二胺。结果：与等摩尔剂量相比，使用加多比鲁的三名志愿者的平均信噪比（SNR）和对比噪声比（CNR）值明显更高（大腿和小腿动脉高达32.5%）。在10例患者中，与数字减影血管造影相比，基于gadobutroll的全身MRA准确评估了显著狭窄（管腔狭窄50%），敏感性和特异性分别为96.2% （95% CI 0.83-0.97）和95.7% （95% CI 0.84-0.96）。结论：使用加多比特提供的全身MRA图像质量优于使用相同剂量的加多比特二聚胺获得的MRA图像质量，因此有希望用作评估整个动脉系统是否存在动脉粥样硬化疾病表现的综合单一检查。
Purpose: To determine whether higher concentrated gadolinium chelates are advantageous for the recently introduced concept of total-body magnetic resonance angiography (MRA), allowing whole-body coverage, extending from the carotid arteries to the runoff vessels, in merely 72 seconds.Materials and Methods: Total-body three-dimensional (3D) MRA using a 1 M Gd-chelate (gadobutrol, Gadovisto, Schering, Berlin, Germany) at a dosage of 0.2 mmol/kg body-weight (biphasic injection protocol: 1.3 mL/second and 0.7 mL/second) was performed on three healthy volunteers and ten consecutive patients with DSA-documented peripheral vascular disease. Separated by at least 72 hours, the three healthy volunteers also underwent the same MRA-protocol, using gadopentetate dimeglumine in equimolar dosages.Results: Compared to equimolar dosages, mean signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) values in the three volunteers were significantly higher (up to 32.5% for the arteries of the thighs and calves) using gadobutrol. In the ten patients, gadobutrol-based total-body MRA accurately assessed significant stenoses (luminal narrowing > 50%) with sensitivities and specificities of 96.2% (95% CI 0.83-0.97) and 95.7% (95% CI 0.84-0.96), respectively, compared to digital subtraction angiography.Conclusion: The MRA image quality for total-body MRA provided by the administration of gadobutrol is superior to that obtained following administration of an identical dose of gadopentetate dimeglumine, and therefore shows promise for use as a comprehensive single exam assessing the entire arterial system for the presence of atherosclerotic disease manifestations.