Inflammation in Alzheimer Disease-A Brief Review of the Basic Science and Clinical Literature
Inflammation in Alzheimer Disease-A Brief Review of the Basic Science and Clinical Literature
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DOI：
10.1101/cshperspect.a006346
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发表时间：
2012-01-01
影响因子：
5.4
通讯作者：
Rogers, Joseph
中科院分区：
文献类型：
--
作者：
Wyss-Coray, Tony;Rogers, Joseph
对阿尔茨海默病（AD）患者大脑的生化和神经病理学研究为炎症通路的激活提供了明确的证据，长期使用抗炎药物与降低患该病的风险有关。由于炎症和AD之间的因果关系正在研究中，人们认识到这种复杂的分子和细胞机制的某些成分很可能促进导致AD的病理过程，而其他成分则起相反的作用。挑战将是找到微调炎症的方法来延迟，预防或治疗AD。
Biochemical and neuropathological studies of brains from individuals with Alzheimer disease (AD) provide clear evidence for an activation of inflammatory pathways, and long-term use of anti-inflammatory drugs is linked with reduced risk to develop the disease. As cause and effect relationships between inflammation and AD are being worked out, there is a realization that some components of this complex molecular and cellular machinery are most likely promoting pathological processes leading to AD, whereas other components serve to do the opposite. The challenge will be to find ways of fine tuning inflammation to delay, prevent, or treat AD.