The past, present, and future of costimulation blockade in organ transplantation.

The past, present, and future of costimulation blockade in organ transplantation.
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器官移植中共刺激阻断的过去、现在和未来。

DOI:
10.1097/mot.0000000000000656
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发表时间:
2019
影响因子:
2.2
通讯作者:
Knechtle,StuartJ
Knechtle,StuartJ
中科院分区:
医学4区
文献类型:
--
作者:
Schroder,PaulM;Fitch,ZacharyW;Schmitz,Robin;Choi,AshleyY;Kwun,Jean;Knechtle,StuartJ

文献摘要

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靶向共刺激是一种很有前途的方法,不仅可以控制T细胞的反应,还可以控制B细胞的反应。因此,共刺激阻断在改善抗体介导的排斥反应和异种移植结果方面显示出相当大的潜力。
Targeting costimultion is a promising approach for not only controlling T cell but also B cell responses. Consequently, costimulation blockade shows considerable potential for improving outcomes in antibody-mediated rejection and xenotransplantation.