The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency
The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency
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DOI：
10.22088/cjim.10.2.125
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发表时间：
2019-01-01
影响因子：
1.4
通讯作者：
Eslami, Bita
中科院分区：
文献类型：
--
作者：
Hajhashemi, Maryam;Ansari, Maryam;Eslami, Bita
背景资料：子宫平滑肌瘤（肌瘤）是育龄妇女中最常见的良性盆腔肿瘤，发病率为5.4%至77%。此外，伊朗维生素D缺乏症的患病率很高，有大量关于维生素D与子宫平滑肌瘤关系的体内和体外生物学研究。本研究的目的是评估维生素D补充剂对子宫平滑肌瘤的大小在妇女维生素D deficiency.Methods：这双盲前瞻性临床试验进行了69例子宫平滑肌瘤谁有维生素D缺乏症。A组（n=35）给予维生素D 50，000 IU，每2周1次，共10周; B组（n=34）给予安慰剂。结果：干预10周后，维生素D治疗组的25-羟维生素D-3水平显著高于对照组（36.08 vs 16.25 ng/ml）。与安慰剂组相比，维生素D组子宫肌瘤体积明显缩小（52.58vs61.11mm，P< 0.001）。维生素D是治疗子宫肌瘤的有效方法。
Background: Uterine leiomyomas (fibroids) are the most common benign pelvic tumors in women of reproductive age with an incidence ranging from 5.4% to 77%, Also, there is a high prevalence of vit D deficiency in Iran and there are the numbers of in vivo and vitro biological studies on the relationship of vitamin D and uterine leiomyomas. The aim of this study was to evaluate the effect of vit D supplementation on the size of uterine leiomyoma in women with vit D deficiency.Methods: This double-blind prospective clinical trial was performed on 69 patients with uterine leiomyomas who had vit D deficiency. Group A (n=35) was treated with vit D 50,000 IU every 2 weeks for 10 weeks, while group B (n=34) received placebo with same color and shape. Finally, the leiomyoma size in both groups was compared (IRCT: 20160521027998N5).Results: After a 10-week intervention, 25-hydroxyvitamin D-3 levels were significantly higher in group receiving vitamin D (36.08 vs 16.25 ng/ml). (P< 0.001) Leiomyomas size in vit D group significantly decreased as compared to placebo group (52.58 vs 61.11 mm, respectively).Conclusion: Our results showed that administration of vit D3 may reduce the size of leiomyoma. It seems that vitamin D administration is the effective way to treat leiomyoma.