Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men.
Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men.
复制标题
DOI：
10.1371/journal.pone.0152748
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Peeters RP
中科院分区：
文献类型：
--
作者：
Beukhof CM;Medici M;van den Beld AW;Hollenbach B;Hoeg A;Visser WE;de Herder WW;Visser TJ;Schomburg L;Peeters RP
硒（Se）状态的细微变化是否会影响甲状腺功能测试（TFTs）和骨矿物质密度（BMD），这仍然是一个争论的问题。这对老年人尤其重要，因为他们的营养状况更脆弱。我们调查了387名健康老年男性（中位年龄77岁，四分位数范围75-80岁）硒水平与TFTs和BMD的关系。硒水平通过血浆硒蛋白P （SePP）和硒含量测定。在我们的人群中，硒的总体状况是低正常的，只有0.5%（2/387）的受试者符合硒缺乏的标准。SePP和Se水平与促甲状腺激素（TSH）、游离甲状腺素（FT4）、甲状腺素（T4）、三碘甲状腺原氨酸（T3）或逆三碘甲状腺原氨酸（rT3）水平无关。反映甲状腺激素外周代谢的T3/T4和T3/rT3比值也与硒水平无关。SePP和Se与总骨密度和股骨粗隆骨密度呈正相关。Se与股骨颈和ward的骨密度呈正相关，而SePP与此无关。多变量线性分析显示，在包括TSH、FT4、体重指数、体能表现评分、年龄、吸烟、糖尿病和用药次数的模型中，这些关联仍然具有统计学意义。我们的研究表明，在正常的欧洲边际供应范围内，硒水平与健康老年男性的骨密度呈正相关，与甲状腺功能无关。在这一人群中，甲状腺功能测试似乎不受硒状况的影响。
It is still a matter of debate if subtle changes in selenium (Se) status affect thyroid function tests (TFTs) and bone mineral density (BMD). This is particularly relevant for the elderly, whose nutritional status is more vulnerable. We investigated Se status in a cohort of 387 healthy elderly men (median age 77 yrs; inter quartile range 75–80 yrs) in relation to TFTs and BMD. Se status was determined by measuring both plasma selenoprotein P (SePP) and Se. The overall Se status in our population was low normal with only 0.5% (2/387) of subjects meeting the criteria for Se deficiency. SePP and Se levels were not associated with thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroxine (T4), triiodothyronine (T3) or reverse triiodothyronine (rT3) levels. The T3/T4 and T3/rT3 ratios, reflecting peripheral metabolism of thyroid hormone, were not associated with Se status either. SePP and Se were positively associated with total BMD and femoral trochanter BMD. Se, but not SePP, was positively associated with femoral neck and ward's BMD. Multivariate linear analyses showed that these associations remain statistically significant in a model including TSH, FT4, body mass index, physical performance score, age, smoking, diabetes mellitus and number of medication use. Our study demonstrates that Se status, within the normal European marginally supplied range, is positively associated with BMD in healthy aging men, independent of thyroid function. Thyroid function tests appear unaffected by Se status in this population.