Neural correlates of cognitive fatigue in multiple sclerosis using functional MRI
Neural correlates of cognitive fatigue in multiple sclerosis using functional MRI
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DOI：
10.1016/j.jns.2008.01.018
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发表时间：
2008-07-15
影响因子：
4.4
通讯作者：
Wylie, Glenn
中科院分区：
文献类型：
--
作者：
DeLuca, John;Genova, Helen M.;Wylie, Glenn
虽然疲劳是多发性硬化症（MS）患者的主要症状之一，但人们对其行为和神经方面的相关性知之甚少。本研究采用了一种新的方法来检测认知疲劳的客观行为表现，同时使用功能磁共振成像监测大脑活动。15名MS患者和15名健康对照者在fMRI采集过程中进行了4次行为任务评估处理速度（mSDMT）试验。据推测，患有多发性硬化症的个体会在特定的大脑区域显示出一种异常的活动模式，这种活动模式在过去被假设为控制疲劳的区域[Chaudhuri A， Behan PO]。疲劳和基底神经节。中华神经科学杂志2000；179:34-42]。具体来说，假设患有多发性硬化症的人在行为表现中表现出比健康对照组更大的大脑激活增加，这被解释为疲劳。虽然MS组明显慢于对照组，但在mSDMT上的表现准确性没有观察到差异。MS组的疲劳行为改变与基底节区、额区（包括上、中、中、下区域）、顶叶区（楔前叶和楔前叶）、丘脑和枕叶的激活增加有关。这些数据为Chaudhuri和Behan的“中枢”疲劳模型提供了直接支持，该模型假设了基底神经节的“非运动”功能的特定作用。(c) 2008 Elsevier B.V.版权所有
Although fatigue is one of the major symptoms of persons with multiple sclerosis (MS), the behavioral and neural correlates are poorly understood. The present study utilized a novel approach to cognitive fatigue examining objective behavioral performance while simultaneously monitoring brain activity using fMRI. Fifteen persons with MS and 15 healthy controls were given 4 trials of a behavioral task assessing processing speed (mSDMT) during fMRI acquisition. It was hypothesized that individuals with MS would show an abnormal pattern of activity across time in specific brain areas previously hypothesized to subserve fatigue [Chaudhuri A, Behan PO. Fatigue and basal ganglia. J Neurol Sci 2000; 179:34-42]. Specifically, it was hypothesized that persons with MS would show a greater increase in cerebral activation across time during behavioral performance than that seen in healthy controls, which was interpreted as fatigue. No difference in performance accuracy on the mSDMT was observed, although the MS group was significantly slower than controls. Behavioral alterations indicative of fatigue in the MS group were associated with increased activation in the basal ganglia, frontal areas including superior, medial, middle and inferior regions, parietal regions (precuneus and cuneus), thalamus and the occipital lobes. These data provide direct support for the Chaudhuri and Behan model of "central" fatigue which hypothesizes a specific role of the "non-motor" functions of the basal ganglia. (c) 2008 Elsevier B.V. All rights reserved.