What We Know About Tuberculosis Transmission: An Overview.

What We Know About Tuberculosis Transmission: An Overview.
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DOI:
10.1093/infdis/jix362
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发表时间:
2017-11-03
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Cardenas V
Cardenas V
中科院分区:
其他
文献类型:
--
作者:
Churchyard G;Kim P;Shah NS;Rustomjee R;Gandhi N;Mathema B;Dowdy D;Kasmar A;Cardenas V

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结核病仍然是一个全球健康问题,造成巨大的疾病负担,2015年估计有1040万新病例。为了阻止结核病的流行,我们必须阻断结核病的传播。此外,阻断结核病传播所需的干预措施必须针对高风险群体和环境。已经提出了结核病传播的简单级联,其中(1)结核病的源病例(2)产生在空气中存活的传染性颗粒(3),以及(4)被易感个体吸入(5),该个体可能被感染,并且(6)然后具有发展结核病的潜力。针对这些事件的干预措施将阻断结核病传播,加速结核病发病率和死亡率的下降。这篇文章的目的是提供一个高层次的概述,什么是已知的结核病传播,使用结核病传播级联作为一个框架,并设置本系列文章的场景,其中涉及结核病传播的具体方面。
Tuberculosis remains a global health problem with an enormous burden of disease, estimated at 10.4 million new cases in 2015. To stop the tuberculosis epidemic, it is critical that we interrupt tuberculosis transmission. Further, the interventions required to interrupt tuberculosis transmission must be targeted to high-risk groups and settings. A simple cascade for tuberculosis transmission has been proposed in which (1) a source case of tuberculosis (2) generates infectious particles (3) that survive in the air and (4) are inhaled by a susceptible individual (5) who may become infected and (6) then has the potential to develop tuberculosis. Interventions that target these events will interrupt tuberculosis transmission and accelerate the decline in tuberculosis incidence and mortality. The purpose of this article is to provide a high-level overview of what is known about tuberculosis transmission, using the tuberculosis transmission cascade as a framework, and to set the scene for the articles in this series, which address specific aspects of tuberculosis transmission.
高艾滋病毒患病率的结核病流行病学和症状疾病的诊断增加。
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