Intraocular penetration of new antiviral agent, hydroxyacyclovir (BW-B759U).
Intraocular penetration of new antiviral agent, hydroxyacyclovir (BW-B759U).
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新型抗病毒剂羟基阿昔洛韦 (BW-B759U) 的眼内渗透。
DOI：
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发表时间：
1986
影响因子：
2.4
通讯作者：
P. D. de Miranda
中科院分区：
文献类型：
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作者：
J. Schulman;G. Peyman;M. Horton;J. Liu;J. Barber;R. Fiscella;P. D. de Miranda
9-[（2-羟基-1-（羟甲基）乙氧基]甲基）鸟嘌呤（羟基阿昔洛韦）是一种核苷类似物，对单纯疱疹病毒1型和2型以及巨细胞病毒（CMV）具有高度功效。这种抗病毒剂对未感染的细胞表现出低毒性。在结膜下、静脉内、玻璃体内和局部给药后，评价了兔的眼内水平。进行了视网膜毒性研究。羟基阿昔洛韦可用于治疗深部疱疹感染、CMV视网膜炎和急性视网膜坏死。
9-[(2-hydroxyl-1-(hydroxymethyl)ethoxy]methyl)guanine (hydroxyacyclovir) is a nucleoside analogue with a high degree of efficacy against herpes simplex virus types 1 and 2 and cytomegalovirus (CMV). This antiviral agent demonstrates a low toxicity towards uninfected cells. Intraocular levels in rabbits were evaluated following subconjunctival, intravenous, intravitreal and topical administration. Retinal toxicity studies were performed. Hydroxyacyclovir may have applications in the treatment of deep herpetic infections, CMV retinitis, and acute retinal necrosis.