Intestinal barrier function: molecular regulation and disease pathogenesis.
Intestinal barrier function: molecular regulation and disease pathogenesis.
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DOI：
10.1016/j.jaci.2009.05.038
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发表时间：
2009-07
影响因子：
14.2
通讯作者：
Hogan, Simon P.
中科院分区：
文献类型：
--
作者：
Groschwitz, Katherine R.;Hogan, Simon P.
肠上皮是单层细胞层，构成了抵御外部环境的最大且最重要的屏障。它作为一种选择性通透屏障，允许营养物质、电解质和水的吸收，同时对管腔内的毒素、抗原和肠道菌群保持有效的防御。上皮通过形成复杂的蛋白质 - 蛋白质网络来维持其选择性屏障功能，这些网络将相邻细胞机械性连接并封闭细胞间隙。连接上皮细胞的蛋白质网络形成三种黏附复合物：桥粒、黏附连接和紧密连接。这些复合物由跨膜蛋白组成，跨膜蛋白在细胞外与相邻细胞相互作用，在细胞内与连接细胞骨架的衔接蛋白相互作用。在过去的十年中，人们越来越认识到肠道屏障功能受损与自身免疫性和炎症性疾病的发展之间存在关联。在这篇综述中，我们总结了对肠道屏障功能的分子组成和调节的不断发展的认识。我们讨论了先天性免疫和适应性免疫与肠上皮屏障功能之间的相互作用，以及外源性因素对肠道屏障功能的影响。最后，我们总结了临床和实验证据，这些证据表明肠上皮屏障功能障碍是导致易患炎症性疾病（包括食物过敏、炎症性肠病和乳糜泻）的一个主要因素。
The intestinal epithelium is a single-cell layer that constitutes the largest and most important barrier against the external environment. It acts as a selectively permeable barrier permitting the absorption of nutrients, electrolytes and water, while maintaining an effective defense against intraluminal toxins, antigens and enteric flora. The epithelium maintains its selective barrier function through the formation of complex protein-protein networks that mechanically link adjacent cells and seal the intercellular space. The protein networks connecting epithelial cells form three adhesive complexes: desmosomes, adherens junctions and tight junctions. These complexes consist of transmembrane proteins that interact extracellularly with adjacent cells and intracellularly with adaptor proteins that link to the cytoskeleton. Over the past decade, there has been increasing recognition of an association between disrupted intestinal barrier function and the development of autoimmune and inflammatory diseases. In this review, we summarize the evolving understanding of the molecular composition and regulation of intestinal barrier function. We discuss the interactions between innate and adaptive immunity and intestinal epithelial barrier function, as well as the impact of exogenous factors on intestinal barrier function. Finally, we summarize clinical and experimental evidence demonstrating intestinal epithelial barrier dysfunction as a major factor contributing to the predisposition to inflammatory diseases including food allergy, inflammatory bowel diseases and celiac disease.
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影响因子：
6.7
作者：
Babinska, A;Kedees, MH;Kornecki, E
通讯作者：
Kornecki, E
DOI：
10.1152/ajpgi.2001.280.6.g1280
发表时间：
2001-06-01
影响因子：
4.5
作者：
Atkinson, KJ;Rao, RK
通讯作者：
Rao, RK
影响因子：
24.5
作者：
Arrieta, M. C.;Madsen, K.;Doyle, J.;Meddings, J.
通讯作者：
Meddings, J.
影响因子：
29.4
作者：
BJARNASON, I;ZANELLI, G;LEVI, AJ
通讯作者：
LEVI, AJ
通过表达突变型紧密连接膜蛋白，细胞旁通透性和跨上皮电阻的功能性分离以及顶端-基底外侧膜内扩散屏障的破坏。
影响因子：
7.8
作者：
Balda, M S;Whitney, J A;Flores, C;Gonzalez, S;Cereijido, M;Matter, K
通讯作者：
Matter, K