Noradrenergic neuromodulation in the olfactory bulb modulates odor habituation and spontaneous discrimination
Noradrenergic neuromodulation in the olfactory bulb modulates odor habituation and spontaneous discrimination
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DOI：
10.1037/a0012522
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发表时间：
2008-08-01
影响因子：
1.9
通讯作者：
Cleland, Thomas A.
中科院分区：
文献类型：
--
作者：
Guerin, Delphine;Didier, Anne;Cleland, Thomas A.
去甲肾上腺素能投射从蓝斑（LC）项目的嗅球（OB），参与气味学习和感知相似的气味之间的分化的皮质结构。作者测试了OB去甲肾上腺素（NA）在短期嗅觉记忆中的作用，使用LC变性加上NA球内输注的动物模型。具体而言，作者用去甲肾上腺素能神经毒素N-乙基-N-（2-氯乙基）-2-溴苄胺盐酸盐（DSP 4）损伤小鼠的皮质去甲肾上腺素能纤维，并测量了对嗅觉习惯化/自发辨别任务的影响。DSP 4处理的小鼠未能习惯于重复的气味呈现，表明它们在5分钟的试验间隔内无法记住气味。然后作者将NA以两种浓度（10（-3）M和10（-5）M，2 μ l/侧）双侧输注到DSP 4治疗组和未损伤对照组动物的OB中。在DSP 4处理的动物，NA管理在任一浓度恢复正常的习惯和自发的歧视性能，表明去甲肾上腺素能神经调节介导这些方面的知觉学习，其疗效不需要活动依赖性的局部调节NA释放。功能OB学习机制可能是必要的正常的气味识别和区分之间的物理相似的气味。
Noradrenergic projections from the locus coeruleus (LC) project to the olfactory bulb (OB), a cortical structure implicated in odor learning and perceptual differentiation among similar odorants. The authors tested the role of OB noradrenaline (NA) in short-term olfactory memory using an animal model of LC degeneration coupled with intrabulbar infusions of NA. Specifically, the authors lesioned cortical noradrenergic fibers in mice with the noradrenergic neurotoxin N-Ethyl-N-(2-chloroethyl)-2-bromobenzylamine hydrochloride (DSP4) and measured the effects on an olfactory habituation/spontaneous discrimination task. DSP4-treated mice failed to habituate to repeated odor presentations, indicating that they could not remember odors over the 5-min intertrial interval. The authors then infused NA bilaterally into the OBs of both DSP4-treated and nonlesioned control animals at two concentrations (10(-3)M and 10(-5)M, 2 mu l/side). In DSP4-treated animals, NA administration at either concentration restored normal habituation and spontaneous discrimination performance, indicating that noradrenergic neuromodulation mediates these aspects of perceptual learning and that its efficacy does not require activity-dependent local regulation of NA release. Functional OB learning mechanisms may be necessary for normal odor recognition and differentiation among physically similar odorants.