Evaluation of Polysaccharopeptide Effects against C6 Glioma in Combination with Radiation
Evaluation of Polysaccharopeptide Effects against C6 Glioma in Combination with Radiation
复制标题
多糖肽联合放射治疗 C6 胶质瘤的疗效评价
作者：
X. Mao;L. M. Green;D. Gridley
目前的治疗方案很少能长期控制高级别脑肿瘤。本研究的主要目的是确定多糖肽（PSP），一种来自云芝（一种真菌）的粗多糖肽提取物，是否可以增强辐射对培养的胶质瘤细胞和体内异种移植肿瘤的影响。PSP能显著增强C6胶质瘤细胞的放射损伤。使用三种不同的时间-剂量方案，用PSP（以2 mg/注射腹膜内注射）和辐射（2戈伊/次，总共8戈伊）处理皮下注射C6细胞的裸鼠。与未处理的荷瘤对照组相比，所有处理组的肿瘤体积始终较小，但在肿瘤植入前接受PSP的一组除外。单独使用放射治疗导致肿瘤进展最慢，而单独使用PSP则没有效果。此外，PSP与放射治疗相结合并没有增加放射疗效。PSP处理动物的血液和脾脏中的自然杀伤细胞、淋巴细胞和粒细胞计数显著升高，表明PSP对免疫功能具有保护作用。总的来说，这些结果保证了进一步的研究，以确定PSP是否可以有效地用于肿瘤和其他疾病的免疫抑制是一个突出的特点上调免疫反应的情况下。
Long-term control of high-grade brain tumors is rarely achieved with current therapeutic regimens. The major goal of this study was to determine whether polysaccharopeptide (PSP), a crude polysaccharide peptide extract derived from Coriolus versicolor, a fungus, could enhance the effects of radiation against glioma cells in culture and in xenografted tumors in vivo. PSP significantly augmented radiation-induced damage to C6 rat glioma cells in vitro. Nude mice injected subcutaneously with the C6 cells were treated with PSP (injected intraperitoneally at 2 mg/injection) and radiation (2 Gy/fraction, 8 Gy in total) using three different time-dose protocols. Tumor volumes were consistently smaller in all treated groups compared to the non-treated tumor-bearing controls except in one group which received PSP prior to tumor implantation. The administration of radiation alone resulted in the slowest tumor progression, whereas PSP alone had no effect. Furthermore, PSP in combination with radiation treatment did not increase radiation efficacy. Natural killer cell, lymphocyte and granulocyte counts in blood and spleen were significantly higher in PSP-treated animals, demonstrating that PSP has protective effects on immunological function. Collectively, these results warrant further investigation to determine if PSP can be effectively utilized to upregulate immune responsiveness in case of neoplasia and other diseases in which immunosuppression is a prominent feature.
多形性胶质母细胞瘤的体内辐射敏感性。
DOI：
10.1016/0360-3016(94)00494-6
发表时间：
1995
期刊：
International journal of radiation oncology, biology, physics.
影响因子：
--
作者：
Taghian,A;DuBois,W;Budach,W;Baumann,M;Freeman,J;Suit,H
通讯作者：
Suit,H