Tubal sterilization in relation to breast cancer risk
Tubal sterilization in relation to breast cancer risk
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DOI：
10.1002/ijc.21582
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发表时间：
2006-04-15
影响因子：
6.4
通讯作者：
Hankinson, SE
中科院分区：
文献类型：
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作者：
Eliassen, AH;Colditz, GA;Hankinson, SE
输卵管绝育方法可能会损害周围组织，可能会破坏卵巢血液供应和激素功能，并可能降低乳腺癌风险。我们在护士健康研究中对77,511名年龄在30-55岁之间的妇女进行了研究，这些妇女在1976年开始随访时没有癌症。从1976年到2000年，我们记录了4,176例浸润性乳腺癌。调整多个乳腺癌风险因素的考克斯比例风险模型提供了率比（RR）和95%置信区间（0）。总体而言，输卵管绝育与乳腺癌风险无关（RR = 0.95，95%CI = 0.88-1.03）。然而，1970年至1974年进行的输卵管绝育手术与风险呈负相关（RR = 0.84，95%CI = 0.73-0.97），而在其他年份进行的手术与风险无关。在1970-1974年进行手术的妇女中，绝育时年龄> 35岁的妇女风险最低（RR = 0.81，95% CI = 0.66-0.98），而年轻妇女的风险降低（RR = 0.87，95% CI = 0.72-1.06）。总体而言，输卵管绝育与乳腺癌风险无关。然而，当通常使用具有潜在破坏性的单极电烙法时，观察到适度的负相关性，这为终生暴露于激素和乳腺癌风险降低之间的关联提供了一些支持。(c)2005 Wiley-Liss，Inc.
Tubal sterilization methods may damage surrounding tissue, potentially disrupting the ovarian blood supply and hormonal functioning, and may decrease breast cancer risk. We examined this hypothesis, within the Nurses' Health Study, among 77,511 women, aged 30-55 years and free of cancer at the start of follow-up in 1976. We documented 4,176 cases of invasive breast cancer from 1976 to 2000. Cox proportional hazards models, adjusting for multiple breast cancer risk factors, provided rate ratios (RR) and 95% confidence intervals (0). Overall, tubal sterilization was not associated with breast cancer risk (RR = 0.95, 95% Cl = 0.88-1.03). However, tubal sterilizations performed from 1970 to 1974 were inversely associated with risk (RR = 0.84, 95% Cl = 0.73-0.97), while procedures performed in other years were not associated with risk. Among women with procedures performed in 1970-1974, those who were > 35 years old at the time of sterilization were at the lowest risk RR = 0.81, 95% Cl = 0.66-0.98), while younger women had a suggested decreased risk (RR = 0.87, 95% Cl = 0.72-1.06). Overall, tubal sterilization was not associated with breast cancer risk. However, a modest inverse association was observed at a time when the potentially destructive unipolar electrocautery method was commonly used, providing some support for an association between lower lifetime exposure to hormones and a decreased risk of breast cancer. (c) 2005 Wiley-Liss, Inc.