PFKFB3 promotes proliferation, migration and angiogenesis in nasopharyngeal carcinoma.
PFKFB3 promotes proliferation, migration and angiogenesis in nasopharyngeal carcinoma.
复制标题
PFKFB3促进鼻咽癌的增殖、迁移和血管生成
DOI：
10.7150/jca.19112
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发表时间：
2017
影响因子：
3.9
通讯作者：
You Y
中科院分区：
文献类型：
--
作者：
Gu M;Li L;Zhang Z;Chen J;Zhang W;Zhang J;Han L;Tang M;You B;Zhang Q;You Y
鼻咽癌（NPC）是一种鳞状上皮癌，起源于鼻咽上皮。它具有很高的发病率和死亡率。PFKFB 3作为糖酵解激活剂与多种类型肿瘤的进展有关。PFKFB 3可促进癌症的进展和转移。然而，PFKFB 3是否与NPC的进展相关仍不清楚。我们推测PFKFB 3在鼻咽癌中促进增殖、迁移和血管生成。在本研究中，我们发现PFKFB 3在NPC组织和细胞系中与正常对照相比显著上调。我们的研究证明PFKFB 3可以调节鼻咽癌的增殖、转移和凋亡。顺便说一句，NPC衍生的外泌体来自CNE 2衍生的外泌体，并且富含PFKFB 3。PFKFB 3的富集在促进HUVECs增殖、迁移和血管生成中发挥了重要的功能作用。肿瘤血管生成与肿瘤的增殖和转移密切相关。总之，我们的研究结果表明，PFKFB 3不仅可以作为血管生成的临床生物标志物，而且可以作为克服血管生成的治疗靶点，增强NPC患者血管生成治疗的临床益处。
Nasopharyngeal carcinoma (NPC) is a squamous epithelial cancer, arising from the nasopharynx epithelium. It has high morbidity and mortality. PFKFB3 as a glycolytic activator has been implicated in the progression of multiple types of tumor. PFKFB3 can be contributed to the progression and metastasis of cancer. However, whether PFKFB3 is associated with the progression of NPC remains unknown. We postulated that PFKFB3 promotes proliferation, migration and angiogenesis in nasopharyngeal carcinoma. In this study, we found that PFKFB3 was significantly up-regulated in NPC tissues and cell lines compared with normal control. Our study proved that PFKFB3 can regulate the proliferation, metastasis and apoptosis of NPC. By the way, the NPC-derived exosomes come from and CNE2-derived exosomes are enriched in PFKFB3. The enrichment of PFKFB3 played a crucial functional role in promotes HUVECs proliferation, migration and angiogenesis. And tumor angiogenesis is closely related to the proliferation and metastasis of tumor. In conclusion, our findings demonstrate that PFKFB3 could act not only as a clinical biomarker for angiogenesis but also as a therapeutic target to overcome angiogenesis, enhancing the clinical benefits of angiogenesis therapy in NPC patients.
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影响因子：
4.6
作者：
Mukai H;Muramatsu A;Mashud R;Kubouchi K;Tsujimoto S;Hongu T;Kanaho Y;Tsubaki M;Nishida S;Shioi G;Danno S;Mehruba M;Satoh R;Sugiura R
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64.5
作者：
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通讯作者：
Carmeliet, Peter
影响因子：
4.6
作者：
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通讯作者：
Whiteside TL
影响因子：
9.7
作者：
Jung, Kyung Hee;Zheng, Hong-Mei;Hong, Soon-Sun
通讯作者：
Hong, Soon-Sun